Results 201 to 210 of about 2,034,258 (266)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Efficacy of sulfonamides targeting malic enzyme in an animal model of Chagas disease. [PDF]

Front Pharmacol
Dos Santos TCF, da Silva RB, de Sousa IL, Naciuk FF, Marchese L, Eufrásio AG, Lobo-Rojas AE, Giampauli RM, de Souza VB, Schenka AA, Bruder M, Rocco SA, Cordeiro AT.   +12 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Assessment of Nociception and Inflammatory/Tissue Damage Biomarkers in a Post-COVID-19 Animal Model. [PDF]

Int J Mol Sci
Sánchez-Robles EM, Rodríguez-Rivera C, Paniagua Lora N, Herradón Pliego E, Goicoechea Garcia C, Arendt-Nielsen L, Fernández-de-Las-Peñas C, López-Miranda V.   +7 more
europepmc   +1 more source

Focused ultrasound-enhanced nose-to-brain delivery of a therapeutic antibody in a large-animal model. [PDF]

Theranostics
Fadera S, Boas CAWV, Yue Y, Gu Z, Yuan J, De D, Rogers BE, Nazeri A, Chen H.   +8 more
europepmc   +1 more source

Fractionation gives therapeutic benefit in animal model of [¹⁷⁷Lu]Lu-PSMA-617 therapy of prostate cancer. [PDF]

EJNMMI Res
Timmermand OV, Östholm A, Zedan W, Strand J, Altai M, Örbom A.   +5 more
europepmc   +1 more source

Correction: Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease. [PDF]

Cell Mol Life Sci
Manso Y, Carrasco J, Comes G, Adlard PA, Bush AI, Hidalgo J.   +5 more
europepmc   +1 more source

Impact of <i>Curcuma longa</i> on Hematopoiesis and Splenic Mass in an Animal Model Undergoing Docetaxel Chemotherapy. [PDF]

Biology (Basel)
Huber IMT, Lourenço ELB, Bellettini ST, Donadel G, Matumoto JFV, Pelloso SM, Dalva de Barros Carvalho M, Rossoni SL, Colferai MMT, Colferai DR, Cuman RKN, Velasquez LG.   +11 more
europepmc   +1 more source