Results 221 to 230 of about 25,135,144 (317)

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source

Effect of Paxlovid on Skeletal System Morphogenesis in Animal Model Rat (Morphological Study). [PDF]

Med J Islam Repub Iran
Abdollahi A, Morovati-Sharifabad M, Salehi E, Rashidi M, Rezaei-Golmisheh A.   +4 more
europepmc   +1 more source

Experimental Animal Models in Respiratory Diseases

Pınar Yildiz Gülhan
openalex   +2 more sources

Diffusion‐based size determination of solute particles: a method adapted for postsynaptic proteins

FEBS Open Bio, EarlyView.
We present a diffusion‐based approach for measuring the size of macromolecules and their complexes, and demonstrate its use on postsynaptic proteins. The method requires fluorescein‐labelled protein samples, a microfluidic device that maintains laminar flow for said samples, a microscope recording the emitted fluorescent signals, and an analytic ...
András László Szabó, Eszter Nagy‐Kanta, Soma Varga, Edit Andrea Jáger, Csaba István Pongor, Mária Laki, András József Laki, Zoltán Gáspári   +7 more
wiley   +1 more source

Altered Inhibitory Synaptic Transmission and Changes in GABAergic Markers in the Hippocampus of Genetic and Environmental Animal Model of Autism. [PDF]

Neurochem Res
Jurkovičová-Tarabová B, Vargovič P, Mihalj D, Havránek T, Jakubíková J, László K, Bačová Z, Bakoš J.   +7 more
europepmc   +1 more source

An animal model of MYC-driven medulloblastoma.

Cancer Cell, 2012
Yanxin Pei, Colin E. Moore, Jun Wang, Alok K. Tewari, A. Eroshkin, Yoon-Jae Cho, H. Witt, A. Korshunov, T. Read, Julia L Sun, E. Schmitt, C. Miller, A. Buckley, R. McLendon, Thomas F. Westbrook, Thomas F. Westbrook, P. Northcott, Michael D. Taylor, S. Pfister, P. Febbo, R. Wechsler-Reya, R. Wechsler-Reya   +21 more
semanticscholar   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source

Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain. [PDF]

JOR Spine
Heimann MK, Tang SN, Gunsch G, Kuchynsky K, Klamer B, Zhao F, Co M, Pietrzak M, Richards J, Klausner J, Smith A, Cimney K, McBride-Gagyi S, Youngblood B, Corps K, Askwith C, Walter BA, Moore SA, Purmessur D.   +18 more
europepmc   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Evaluating Parkinson's disease biomarkers in substantia nigra following sublethal γ-radiation exposure in a large animal model. [PDF]

NPJ Parkinsons Dis
Murphy EK, Perl DP, Day RM, Iacono D.
europepmc   +1 more source