Results 221 to 230 of about 3,851,825 (350)

Chondrodystrophic Dogs as a Preclinical Large Animal Model of Discogenic Back Pain. [PDF]

JOR Spine
Heimann MK, Tang SN, Gunsch G, Kuchynsky K, Klamer B, Zhao F, Co M, Pietrzak M, Richards J, Klausner J, Smith A, Cimney K, McBride-Gagyi S, Youngblood B, Corps K, Askwith C, Walter BA, Moore SA, Purmessur D.   +18 more
europepmc   +1 more source

Animal model for evaluating the convulsive liability of beta-lactam antibiotics [PDF]

, 1988
Patricia D. Williams, Damien Bennett, C. R. Comereski   +2 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Investigation of intrapartum clearence of the upper airway in the presence of meconium contaminated amniotic fluid using an animal model

, 1984
E. Pfenninger, W. Dick, D. Brecht-Krauß, F. Bitter, H. Hofmann, I. Bowdler   +5 more
openalex   +2 more sources

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

The renoprotective effects of tadalafil on ischemia-reperfusion injury during partial nephrectomy in an animal model. [PDF]

BMC Nephrol
Lee EH, Yoo ES, Yoon BH, Jeon M, Kwon TG, Kim BS, Ha YS, Han MH, Song PH, Chung JW.   +9 more
europepmc   +1 more source

Animal Models of Inherited Metabolic Diseases [PDF]

, 1983
A. D. Patrick
openalex   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

In Situ Bioprinting Enhances Bone Regeneration in a Live Animal Model with Craniofacial Defect. [PDF]

ACS Biomater Sci Eng
Hindi OA, Pinarbasi B, Bakici M, Demirtas OB, Gokyer S, Buyuksungur A, Orhan K, Oto C, Yilgor P.   +8 more
europepmc   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source