Results 351 to 360 of about 26,422,673 (403)
Some of the next articles are maybe not open access.
CRISPR in Animals and Animal Models
2017CRISPR-Cas9 has revolutionized the generation of transgenic animals. This system has demonstrated an unprecedented efficiency, multiplexability, and ease of use, thereby reducing the time and cost required for genome editing and enabling the production of animals with more extensive genetic modifications.
Ellen Shrock, Marc Güell, Marc Güell
openaire +3 more sources
Drug Safety, 1990
A review of the major categories of animal test procedures used in the toxicological assessment of drugs is presented. Problems that persist include low incidence responses, the need for innovation in toxicological methods and current societal attitudes about drugs and chemicals.
openaire +3 more sources
A review of the major categories of animal test procedures used in the toxicological assessment of drugs is presented. Problems that persist include low incidence responses, the need for innovation in toxicological methods and current societal attitudes about drugs and chemicals.
openaire +3 more sources
An ecologist's guide to the animal model.
Journal of Animal Ecology, 20101. Efforts to understand the links between evolutionary and ecological dynamics hinge on our ability to measure and understand how genes influence phenotypes, fitness and population dynamics.
Alastair J. Wilson +7 more
semanticscholar +1 more source
Clinics in Dermatology, 2007
Research into the pathogenesis of psoriasis has been severely hampered by the lack of a naturally occurring disorder in laboratory animals that mimics the complex phenotype and pathogenesis of the human disease. A large variety of spontaneous mutations, genetically engineered rodents, immunological reconstitution approaches, and xenotransplantation ...
Boehncke, Wolf-Henning +1 more
openaire +4 more sources
Research into the pathogenesis of psoriasis has been severely hampered by the lack of a naturally occurring disorder in laboratory animals that mimics the complex phenotype and pathogenesis of the human disease. A large variety of spontaneous mutations, genetically engineered rodents, immunological reconstitution approaches, and xenotransplantation ...
Boehncke, Wolf-Henning +1 more
openaire +4 more sources
Sensorimotor gating and schizophrenia. Human and animal model studies.
Archives of General Psychiatry, 1990Human and animal model studies of sensorimotor gating allow us to understand the functional significance of attentional abnormalities and monoaminergic alterations in patients with schizophrenic disorders.
D. Braff, M. Geyer
semanticscholar +1 more source
Animal Models of Osteomyelitis
The International Journal of Artificial Organs, 2006There are numerous reports in the literature using animal models of osteomyelitis for investigating pathogenesis, diagnosis, and treatment of bone infections. Rabbits, rats, and dogs are commonly used animals, and, less frequently, chickens, guinea pigs, miniature pigs, goats, and sheep.
An Y. H. +2 more
openaire +4 more sources
2002
Neurobiologi, dyremodeller, psykiatri, adfærdsmetoder, artssammenligninger ...
openaire +2 more sources
Neurobiologi, dyremodeller, psykiatri, adfærdsmetoder, artssammenligninger ...
openaire +2 more sources
2010
As clinical studies reveal that chemotherapeutic agents may impair several different cognitive domains in humans, the development of preclinical animal models is critical to assess the degree of chemotherapy-induced learning and memory deficits and to understand the underlying neural mechanisms.
openaire +2 more sources
As clinical studies reveal that chemotherapeutic agents may impair several different cognitive domains in humans, the development of preclinical animal models is critical to assess the degree of chemotherapy-induced learning and memory deficits and to understand the underlying neural mechanisms.
openaire +2 more sources
Pancreatology, 2006
Research on basic mechanisms that regulate pancreatic organogenesis may help to define molecular pathways involved in the development of pancreatic diseases. In this regard, animal models have become an essential part of advancing our research efforts.
openaire +2 more sources
Research on basic mechanisms that regulate pancreatic organogenesis may help to define molecular pathways involved in the development of pancreatic diseases. In this regard, animal models have become an essential part of advancing our research efforts.
openaire +2 more sources
2018
The diagnosis of vasculitis in rheumatoid arthritis (RV) is associated with considerable mortality; therefore, understanding the basic mechanisms underlying the pathogenesis of vasculitis is very important. Animal models of vasculitis have contributed to elucidating such mechanisms. We here introduce a Candida albicans water-soluble glycoprotein (CAWS)-
M Mogi, Shuang Liu
openaire +4 more sources
The diagnosis of vasculitis in rheumatoid arthritis (RV) is associated with considerable mortality; therefore, understanding the basic mechanisms underlying the pathogenesis of vasculitis is very important. Animal models of vasculitis have contributed to elucidating such mechanisms. We here introduce a Candida albicans water-soluble glycoprotein (CAWS)-
M Mogi, Shuang Liu
openaire +4 more sources