Results 51 to 60 of about 27,577,089 (399)

Animal Models in Osteosarcoma [PDF]

Frontiers in Oncology, 2014
Osteosarcoma (OS) is the most common non-hematologic primary tumor of bone in children and adults. High-dose cytotoxic chemotherapy and surgical resection have improved prognosis, with long-term survival for non-metastatic disease approaching 70%. However, most OS tumors are high grade and tend to rapidly develop pulmonary metastases.
Guijarro, Maria V., Ghivizzani, Steven C., Gibbs, C. Parker   +2 more
openaire   +3 more sources

TBX2 affects proliferation, apoptosis and cholesterol generation by regulating mitochondrial function and autophagy in bovine cumulus cell

Veterinary Medicine and Science, 2023
Background T‐box transcription factor 2 (TBX2) is a member of T‐box gene family whose members are highly conserved in evolution and encoding genes and are involved in the regulation of developmental processes. The encoding genes play an important role in
Sheng‐Peng Li, Hao Jiang, Zi‐Bin Liu, Wen‐Jie Yu, Xiao‐Shi Cai, Chang Liu, Wen‐Yin Xie, Fu‐shi Quan, Wei Gao, Nam‐Hyung Kim, Bao Yuan, Cheng‐Zhen Chen, Jia‐Bao Zhang   +12 more
doaj   +1 more source

Molecular Model of the Contractile Ring

, 2005
We present a model for the actin contractile ring of adherent animal cells. The model suggests that the actin concentration within the ring and consequently the power that the ring exerts both increase during contraction.
D. Biron, D. Biron, D. Humphrey, D. H. Boal, E. Alvarez-Lacalle, E. Moses, I. Mabuchi, I. Mabuchi, J. Howard, O. Thoumine, R. Rappaport, R. L. Debiasio, T. Tlusty, T. D. Pollard, T. E. Schroeder, T. E. Schroeder   +15 more
core   +1 more source

HAX1 inhibits apoptosis and promotes maturation of neutrophils

Cell Communication and Signaling
As the diverse functions of neutrophils continue to be uncovered, elucidating the molecular mechanisms that regulate their differentiation, development, and apoptosis has become crucial for overcoming limitations in the treatment of neutrophil-related ...
Hanwei Yue, Guiying Shi, Jiaming Tang, Xinyue Li, Lin Bai   +4 more
doaj   +1 more source

Exploring the Validity of Valproic Acid Animal Model of Autism

Experimental Neurobiology, 2015
The valproic acid (VPA) animal model of autism spectrum disorder (ASD) is one of the most widely used animal model in the field. Like any other disease models, it can't model the totality of the features seen in autism. Then, is it valid to model autism?
Darine Froy N. Mabunga, E. L. Gonzales, Ji-Woon Kim, Ki Chan Kim, C. Shin   +4 more
semanticscholar   +1 more source

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source

The Chihuahua dog: A new animal model for neuronal ceroid lipofuscinosis CLN7 disease? [PDF]

, 2016
Neuronal ceroid lipofuscinoses (NCLs) are a group of incurable lysosomal storage disorders characterized by neurodegeneration and accumulation of lipopigments mainly within the neurons. We studied two littermate Chihuahua dogs presenting with progressive
Alroy, Joseph, Anderson, Glenn W., Bras, Jose, Darwent, Lee, Faller, Kiterie M.E., Guerreiro, Rita J., Gutierrez Quintana, Rodrigo, Kun-Rodrigues, Celia, Mole, Sara E., Penderis, Jacques, Sharpe, Samuel J.   +10 more
core   +2 more sources

Awake chronic mouse model of targeted pial vessel occlusion via photothrombosis [PDF]

, 2020
Animal models of stroke are used extensively to study the mechanisms involved in the acute and chronic phases of recovery following stroke. A translatable animal model that closely mimics the mechanisms of a human stroke is essential in understanding ...
Boas, David A., Chen, Ichun Anderson, Cheng, Xiaojun, Erdener, Sefik Evren, Kılıç, Kıvılcım, Kura, Sreekanth, Lee, Blaire Ss, Postnov, Dmitry, Sunil, Smrithi, Tang, Jianbo   +9 more
core   +1 more source

Personalizing the Pediatric Hematology/Oncology Fellowship: Adapting Training for the Next Generation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The pediatric hematology‐oncology fellowship training curriculum has not substantially changed since its inception. The first year of training is clinically focused, and the second and third years are devoted to scholarship. However, this current structure leaves many fellows less competitive in the current job market, resulting in ...
Scott C. Borinstein, Melissa J. Rose, Scott Moerdler, Richard Ho   +3 more
wiley   +1 more source

Insight into pericytes in glioblastoma angiogenesis: In vivo tracking by two‐photon microscopy and proteomic profiling

Animal Models and Experimental Medicine
Background Glioblastoma (GBM) is a highly aggressive brain tumor characterized by aberrant angiogenesis and an immunosuppressive microenvironment. Pericytes are aberrantly recruited but their spatiotemporal roles and molecular changes remain unclear ...
Qinghong Wang, Chengyan Ma, Xinpei Wang, Mengyuan Li, Xingjiu Yang, Ran Gao   +5 more
doaj   +1 more source