Results 201 to 210 of about 1,661,237 (266)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Establishment and translational evaluation of animal models for skin wound healing: a systematic review. [PDF]

Front Physiol
Zhang Y, Leng K, Dong M, Wu J, Wang Z, Zhu Q, Gao X, Sun Y.   +7 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Brucellosis vaccine development: immunological mechanisms, animal models, and future directions. [PDF]

Arch Microbiol
Zhang Y, Li D, Wang B, Li X, Qi Y, Ding H.   +5 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Animal models of Huntington's disease. Pros and cons. [PDF]

Brain Behav Immun Health
Stepanova P, Voutilainen MH, Eriksson O, Lindholm D.   +3 more
europepmc   +1 more source

Multi-dimensional decoding of the TSPO signal in animal models of neuroinflammation using fluorescence-conjugated DPA714. [PDF]

J Neuroinflammation
Song H, Zhu Z, Xiao L, Zhao Q, Li C, Lv A, Yu X, Gao Z, Lin J, Wang Y, Zhang Y, Zhang L, Li R, Yao S, Cui M, Lin Y, Fu Y, Yong VW, Li R.   +18 more
europepmc   +1 more source

Exploring the Animal Models of Gastrointestinal and Emotional Comorbidity. [PDF]

Brain Behav
Wang YH, Kong XR, Ye XZ, Pu S, Ren XX, Huang QY, Lu YQ, Wang H.   +7 more
europepmc   +1 more source

Animal models and pathogenesis of gastric cancer: from premalignant conditions-to-metastasis. [PDF]

Cancer Biol Med
Pan Y, Zhao L, Fang J.
europepmc   +1 more source