Results 231 to 240 of about 3,107,608 (303)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Research advances in dysphagia animal models. [PDF]

Animal Model Exp Med
Bai J, Cheng K, Zhang N, Chen Y, Ni J, Wang Z.   +5 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

An Experimental Study to Evaluate the Role of Buprenorphine, Morphine, and Naltrexone in Animal Models of Depression. [PDF]

Cureus
Suja Nongtdu NL, Verma V.
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Current State-of-the-Art Animal Models of Pediatric Brain Tumors. [PDF]

Brain Sci
Gudavalli T, Lam FC, Guru S, AbuReesh D, Hori YS, Hiniker S, Park DJ, Chang SD.   +7 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Beyond joints: the importance of animal models in exploring rheumatoid arthritis comorbidities. [PDF]

Front Med (Lausanne)
Marco-Bonilla M, Fresnadillo M, de la Riva-Bueno M, Herrero-Beaumont G, González-Gay MA, Largo R, Mediero A.   +6 more
europepmc   +1 more source

Gold Nanoparticles for Wound Healing in Animal Models. [PDF]

Nanomaterials (Basel)
Klavsen S, Rasmussen S.
europepmc   +1 more source

Researcher's guide to preclinical animal models of acute extremity compartment syndrome. [PDF]

Trauma Surg Acute Care Open
Gaeth CC, Moritz RJ, Seidelmann M, Cognetti DJ.   +3 more
europepmc   +1 more source