Results 231 to 240 of about 9,617,823 (263)

PAK1 expression protects cellular and behavioral defects in animal models of Parkinson' s disease. [PDF]

Mol Brain
Kim JE, Lee K, Kim HJ, Oh WJ, Kim HK.
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Large animal models for the assessment of snakebite envenoming therapies. [PDF]

NPJ Drug Discov
Benard-Valle M, Ahmadi S, Modahl CM, Neri-Castro E, Alagón A, Boyer L, Ljungars A, Laustsen AH.   +7 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Animal models of allergic rhinitis: current progress and advances in traditional Chinese medicine syndrome models. [PDF]

Front Allergy
Yang C, Yee SS, Feng H, Zhao J.
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Exploring Genetic Therapies Targeting Amyotrophic Lateral Sclerosis in Animal Models: A Systematic Review and Meta-Analysis. [PDF]

J Gene Med
Wedgwood HE, Tuxworth RI, Ahmed Z.
europepmc   +1 more source

Research progress on the mechanisms and animal models of Ménière's disease. [PDF]

Genes Dis
Liu S, Li Y, Zhang Y, Zheng Y, Jin C, Chen L, Hu G, Zuo W.   +7 more
europepmc   +1 more source

Selected Large-Animal Models of Ventricular Arrhythmias. [PDF]

Biology (Basel)
Frydrychowski P, Cepiel-Kośmieja A, Wojtczak Z, Nowak K, Noszczyk-Nowak A.   +4 more
europepmc   +1 more source

Natural products as modulators of age-associated gut microbiota dysbiosis: a systematic review of animal models. [PDF]

Front Pharmacol
Saud Gany SL, Mohd Sahardi NFN, Rusli N, Mohd Zaffarin AS, Razak AM, Makpol S.   +5 more
europepmc   +1 more source