Results 271 to 280 of about 1,819,816 (315)
Some of the next articles are maybe not open access.
Clinics in Dermatology, 2007
Research into the pathogenesis of psoriasis has been severely hampered by the lack of a naturally occurring disorder in laboratory animals that mimics the complex phenotype and pathogenesis of the human disease. A large variety of spontaneous mutations, genetically engineered rodents, immunological reconstitution approaches, and xenotransplantation ...
Boehncke, Wolf-Henning +1 more
openaire +3 more sources
Research into the pathogenesis of psoriasis has been severely hampered by the lack of a naturally occurring disorder in laboratory animals that mimics the complex phenotype and pathogenesis of the human disease. A large variety of spontaneous mutations, genetically engineered rodents, immunological reconstitution approaches, and xenotransplantation ...
Boehncke, Wolf-Henning +1 more
openaire +3 more sources
2010
As clinical studies reveal that chemotherapeutic agents may impair several different cognitive domains in humans, the development of preclinical animal models is critical to assess the degree of chemotherapy-induced learning and memory deficits and to understand the underlying neural mechanisms.
openaire +2 more sources
As clinical studies reveal that chemotherapeutic agents may impair several different cognitive domains in humans, the development of preclinical animal models is critical to assess the degree of chemotherapy-induced learning and memory deficits and to understand the underlying neural mechanisms.
openaire +2 more sources
Animal Models of Osteoarthritis
Biorheology: The Official Journal of the International Society of Biorheology, 1999Animal models have proved to be of considerable importance in elucidating mechanisms underlying joint damage in osteoarthritis (OA) and providing proof of concept in the development of pharmacologic and biologic agents that may modify structural damage in the OA joint.
openaire +2 more sources
Growing and Animating Polygonal Models of Animals
Computer Graphics Forum, 1997While there exist many computer models of animal bodies, as polygonal meshes and parametric surfaces, these are difficult to modify to take growth into account, or to animate. Growth data available from the literature usually is expressed as very sparse measurements over the body at various ages of the animal.
Marcelo Walter, Alain Fournier
openaire +1 more source
2018
Animal assays represent an important stage between in vitro studies and human clinical applications. These models are crucial for biomedical research and regenerative medicine studies, as these offer precious information for systematically assessing the efficacy and risks of recently created biomaterials, medical devices, drugs, and therapeutic ...
da Silva Morais, Alain +2 more
openaire +3 more sources
Animal assays represent an important stage between in vitro studies and human clinical applications. These models are crucial for biomedical research and regenerative medicine studies, as these offer precious information for systematically assessing the efficacy and risks of recently created biomaterials, medical devices, drugs, and therapeutic ...
da Silva Morais, Alain +2 more
openaire +3 more sources
2003
Cancer is a prevalent and poorly understood disease in human populations. It is generally viewed as a complex, genetic, multistep process involving a series of independent events, each of which creates an incremental phenotypic aberration. For example, the capabilities for extended proliferation, invasion of adjacent tissue, and distant metastasis ...
C T, Guy, G, Cardoso
openaire +2 more sources
Cancer is a prevalent and poorly understood disease in human populations. It is generally viewed as a complex, genetic, multistep process involving a series of independent events, each of which creates an incremental phenotypic aberration. For example, the capabilities for extended proliferation, invasion of adjacent tissue, and distant metastasis ...
C T, Guy, G, Cardoso
openaire +2 more sources
Hearing Research, 2016
Presented is a thematic review of animal tinnitus models from a functional perspective. Chronic tinnitus is a persistent subjective sound sensation, emergent typically after hearing loss. Although the sensation is experientially simple, it appears to have central a nervous system substrate of unexpected complexity that includes areas outside of those ...
Thomas J, Brozoski, Carol A, Bauer
openaire +2 more sources
Presented is a thematic review of animal tinnitus models from a functional perspective. Chronic tinnitus is a persistent subjective sound sensation, emergent typically after hearing loss. Although the sensation is experientially simple, it appears to have central a nervous system substrate of unexpected complexity that includes areas outside of those ...
Thomas J, Brozoski, Carol A, Bauer
openaire +2 more sources
Psychosomatics, 1992
This study describes an animal model for delirium comparing rats treated with either saline or atropine. The model was defined by recordings of cortical EEGs, maze performance, and behavioral observations. EEG slowing and increased amplitude, difficulty with attention and memory, sleep-wake cycle reversal, and changes in behavior (lack of focused ...
P T, Trzepacz, M, Leavitt, K, Ciongoli
openaire +2 more sources
This study describes an animal model for delirium comparing rats treated with either saline or atropine. The model was defined by recordings of cortical EEGs, maze performance, and behavioral observations. EEG slowing and increased amplitude, difficulty with attention and memory, sleep-wake cycle reversal, and changes in behavior (lack of focused ...
P T, Trzepacz, M, Leavitt, K, Ciongoli
openaire +2 more sources
Disability and Rehabilitation, 2008
The term tendinopathy describes non-ruptured tendon injuries. While several important studies have evaluated the aetiology, pathogenesis, and treatment of this common condition, further study is needed. Several animal models, which allow for full tissue evaluation on different organizational levels and stages of disease, have been used to investigate ...
Spencer P, Lake +2 more
openaire +2 more sources
The term tendinopathy describes non-ruptured tendon injuries. While several important studies have evaluated the aetiology, pathogenesis, and treatment of this common condition, further study is needed. Several animal models, which allow for full tissue evaluation on different organizational levels and stages of disease, have been used to investigate ...
Spencer P, Lake +2 more
openaire +2 more sources
Trends in Cardiovascular Medicine, 1994
Percutaneous transluminal coronary angioplasty is a widely used technique for recanalizing arteries that are occluded by atherosclerotic plaque, but its usefulness is limited by the occurrence ofrestenosis in a high proportion of patients. The development of new therapies for this currently intractable problem will be facilitated by the use of animal ...
openaire +2 more sources
Percutaneous transluminal coronary angioplasty is a widely used technique for recanalizing arteries that are occluded by atherosclerotic plaque, but its usefulness is limited by the occurrence ofrestenosis in a high proportion of patients. The development of new therapies for this currently intractable problem will be facilitated by the use of animal ...
openaire +2 more sources