Results 111 to 120 of about 30,399 (216)

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

Dietary biological silage from tambaqui by products affect performance, physiology, and egg quality of young and old laying hens. [PDF]

Trop Anim Health Prod
Guimarães CC, Rufino JPF, Barai AA, de Almeida Santos AN, da Silva Gomes MF, Nóbrega TC, Ribeiro MWS, da Silva Castro PD, Mendes JM, de Lima Chaves FA, da Silva Junior JL, de Freitas Mendonça MA, de Jesus Beltrão Machado N, de Oliveira AT.   +13 more
europepmc   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Effect of zinc oxide nanoparticle supplementation in Santa Inês ewes during the transition period. [PDF]

Trop Anim Health Prod
Pinchao WHP, Guedes HB, Jimenez CR, Moreira GR, Fernandes MA, Costa BGS, Katiki LM, Fernandes EAN, Mena MO, Bassetto CC, Albuquerque ACA, Amarante AFTD, Louvandini H.   +12 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Novel Insights into the Regulation of GnRH Secretion in Sheep Hypothalamic Nerve Cells by the <i>GRM1</i> Gene. [PDF]

Int J Mol Sci
Zhai M, Zheng W, Zhao Z, Xie Y.
europepmc   +1 more source

Nutritional properties, traditional uses and potential new applications for the sotol plant (Asparagaceae, Convallarioideae): A review

PLANTS, PEOPLE, PLANET, EarlyView.
Sotol (Dasylirion spp.) is a resilient desert plant that sustains ecosystems, cultures and livelihoods in Chihuahua Desert. Our review highlights its nutritional properties, traditional uses and potential new applications in food, pharmaceuticals, renewable energy and water remediation. By synthesizing evidence across disciplines, we show how sotol can
Dámaris Leopoldina Ojeda Barrios, Antonio Martínez Ruiz, Marisela Calderón Jurado, Ramón Saúl Luján Aguirre, Juan Luis Jacobo Cuellar, Oscar Sariñana‐Aldaco, María Teresa Martínez Damián, Oscar Cruz Alvarez   +7 more
wiley   +1 more source

Comparative renal physiology and excretory adaptations in ruminants and poultry: Implications for nutrition, health, and environmental management. [PDF]

Poult Sci
Gobezie D.
europepmc   +1 more source

Sublethal herbicide exposure alters cotton susceptibility to aphid infestation

Pest Management Science, EarlyView.
Sublethal herbicide exposure altered cotton susceptibility to aphids. Aphid severity was highest when applications occurred at early vegetative stages and declined as the crop matured. In glasshouse, herbicide effects were dose‐dependent. Abstract BACKGROUND Herbicides remain vital tools for weed control, yet their effects can extend beyond weeds to ...
Purushottam Gyawali, Ubaldo Torres, David L Kerns, Gregory A Sword, Muthukumar V Bagavathiannan   +4 more
wiley   +1 more source

Beyond 25(OH)D: Carboxylated Osteocalcin and the Undercarboxylated/Carboxylated Osteocalcin Ratio as Superior Biomarkers for Vitamin D Recovery in Offspring Affected by Maternal Deficiency. [PDF]

Nutrients
Chan WT, Lee HC, Yeung CY, Chiang Chiau JS, Cheng ML, Chang SW, Weng SC, Jiang CB.   +7 more
europepmc   +1 more source