Results 121 to 130 of about 54,071 (216)

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

open access: yesMed Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang   +12 more
wiley   +1 more source

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

open access: yesMed Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

When the Scale Drops: Pathways to Weight Loss in Parkinson's Disease and Future Directions

open access: yesMovement Disorders, EarlyView.
Abstract Although Parkinson's disease (PD) is classically defined by its motor features, non‐motor symptoms exert a substantial and often under‐recognized influence on disease trajectory. Among these, weight loss has long been observed in PD and other neurodegenerative disorders, yet the mechanisms remain incompletely understood.
Ellie D. Gabriel   +6 more
wiley   +1 more source

Maternal undernutrition reprograms reproductive and metabolic phenotypes in female offspring of the rabbit model. [PDF]

open access: yesPLoS One
Arias-Alvarez M   +8 more
europepmc   +1 more source

The niche variation hypothesis predicts hunting returns across human cultures

open access: yesOikos, EarlyView.
The niche variation hypothesis (NVH) proposes that a broader population niche arises from greater individual specialization. Despite decades of empirical testing, research remains constrained to non‐human foragers, and the generality of NVH may extend beyond wildlife. The analysis of > 8000 hunting records from 12 human societies across four continents
Raul Costa‐Pereira
wiley   +1 more source

Quantitative synthesis of the effects of drought on community composition and species interactions in terrestrial ecosystems

open access: yesOikos, EarlyView.
Droughts, increasingly frequent under human‐driven climate change, are expected to intensify globally. Both pulsed and prolonged droughts can strongly affect organismal survival and population dynamics, potentially altering terrestrial communities and ecosystems.
Mattheau S. Comerford   +14 more
wiley   +1 more source

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