Results 91 to 100 of about 879,291 (289)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Counting the chorus: A bioacoustic indicator of population density

Ecological Indicators
Passive acoustic monitoring has grown in utility for tracking wildlife populations, although challenges remain when using acoustic detections to monitor population size and density.
Amanda K. Navine, Richard J. Camp, Matthew J. Weldy, Tom Denton, Patrick J. Hart   +4 more
doaj   +1 more source

Population Estimation and Trappability of the European Badger (Meles meles): Implications for Tuberculosis Management.

, 2012
peer-reviewedEstimates of population size and trappability inform vaccine efficacy modelling and are required for adaptive management during prolonged wildlife vaccination campaigns.
Corner, L. A. (Leigh Austin), Stuart Green (113477), Byrne Andrew W., Andrew W Byrne, Murphy, Denise, Eamonn Gormley (84870), Leigh A. L. Corner (113481), D. Paddy Sleeman (113479), Martin, S. Wayne, Stuart Green, John Davenport (113486), D Paddy Sleeman, S Wayne Martin, Gormley, Eamonn, O'Keeffe, James, Davenport John, Sleeman D. Paddy, green, stuart, Denise Murphy, Eamonn Gormley, Gormley Eamonn, John Davenport, Corner Leigh A. L., Denise Murphy (113482), Davenport, John, O’Keeffe James, Corner, Leigh A. L., James O’Keeffe (113475), Green Stuart, Murphy Denise, Byrne, Andrew W., Andrew W. Byrne (113473), James O'Keeffe, Martin S. Wayne, S. Wayne Martin (113484), Leigh A L Corner, et al., Sleeman, D. Paddy   +37 more
core   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Aspectos biodemográficos de grupos étnicos Macro-Pano de Bolivia y caracterización genética de las poblaciones Aymará, Quechua, Chimane y Mosetén [PDF]

, 2011
[spa] La tesis trata de definir algunos aspectos de la situación demográfica y describir la genética poblacional a partir del estudio de haplogrupos del ADN mitocondrial (ADNmt), secuenciación de la región de control d-loop del ADNmt (HVRI), de ...
Bert i Fibla, Francesc
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Trends, drivers, and reduction pathways for food-related greenhouse gas emissions in China: 1961–2050

Chinese Journal of Population, Resources and Environment
Greenhouse gas (GHG) emissions from China’s food system are a major environmental concern; however, studies quantifying their drivers and future projections remain limited.
Jinyu Han, Jiansheng Qu, Tek Narayan Maraseni, Dai Wang, Jianpeng Zhang, Li Xu, Yujie Ge, Dingye Wu   +7 more
doaj   +1 more source

Genetic Groups in an Animal Model

, 1988
Rules are presented for assigning coefficients to the genetic group portion(s) of the mixed model equations after transformation to solve directly for total genetic value (group plus animal solutions) simultaneously for sires and cows using an animal ...
Van Vleck, L. Dale, Quaas, R. L., Westell, R. A.   +2 more
core  

Zoo Animal Welfare

This is an Accepted Manuscript of a book chapter published by CRC Press in [Zoo Animal Welfare] on [21/11/2025], available online: https://www.routledge.com/Zoo-Animal-Welfare/Rose-Newnham-Hickey/p/book/9781032547367One of the roles of a modern zoo is to
Beilby, Jonathan, Stanley, Christina R., Costa, William   +2 more
core   +1 more source