Results 71 to 80 of about 879,291 (289)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Diffusion of Social Information in Non-grouping Animals

Frontiers in Ecology and Evolution, 2020
Recent findings indicate that the utilization of social information, produced inadvertently by other individuals through their spatial location and/or interaction with the environment, may be ubiquitous in the animal kingdom.
Zoltán Tóth, Boglárka Jaloveczki, Gergely Tarján   +2 more
doaj   +1 more source

Spatially structured genetic variation in a broadcast spawning bivalve: quantitative vs. molecular traits [PDF]

, 2003
Understanding the origin, maintenance and significance of phenotypic variation is one of the central issues in evolutionary biology. An ongoing discussion focuses on the relative roles of isolation and selection as being at the heart of genetically based
Drent, J., Delden, W. van,, J. Drent, Piersma, T.,, Luttikhuizen, PC, Drent, J, Luttikhuizen, P.C., Piersma, T, Piersma, T.; id_orcid, Luttikhuizen, P.C.,, T. Piersma, van Delden, W, P. C. Luttikhuizen, Drent, J.,, Piersma, T., van Delden, W., W. Van Delden   +16 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Fitness-associated consequences of an omnivorous diet for the mangrove tree crab Aratus pisonii

Aquatic Biology, 2014
Omnivory is a widespread trophic strategy with variable impacts on survival and reproduction, even within closely related taxonomic groups. In coastal ecosystems experiencing extensive environmental changes, many decapod crustaceans employ omnivorous ...
ME Riley, M Vogel, BD Griffen
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

The effect of Animal-assisted therapy on prosocial behavior and emotional regulation in autistic children with varying verbal abilities: A pilot study.

PLoS ONE
BackgroundThe use of animal-assisted therapy (AAT) has increased in the pediatric autism population. However, studies detailing differences in human-animal interaction between autistic children and animals along with the longevity of reported outcomes ...
Michele Kilmer, Minju Hong, Victor Akakpo, Terria Hawley, Danielle Randolph, Sarah Huetter, Allison Reichel, Madelyn Bowden   +7 more
doaj   +1 more source

THE SOCIETY’S PERCEPTION OF THE LIFE QUALITY AND POPULATION CONTROL OF STRAY DOGS

Ciência Animal Brasileira, 2015
In most Brazilian municipalities there is an overpopulation of stray dogs, which causes problems to the urban order, the environment and the public health, in addition to mistreatment to these dogs.
Flavio Fernando Batista Moutinho, Elmiro Rosendo do Nascimento, Rita Leal Paixão   +2 more
doaj   +1 more source

Modelagem da dinâmica populacional e social de Sotalia guianensis (Cetacea: Delphinidae) [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Ecologia, Florianópolis, 2011Sistemas complexos têm fascinado cientistas com sua auto-organização e propriedades emergentes. Este
Magnani, Mauricio Neves Cantor
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source