Results 111 to 120 of about 97,309 (272)

Functional compressive mechanics and tissue biocompatibility of an injectable SF/PU hydrogel for nucleus pulposus replacement

Scientific Reports, 2017
In spinal degenerative disease, an injectable liquid hydrogel can fill in defect entirely, lessen the danger of implant relocation and following loss of disc height, minimizing the operative trauma. Here, we propose an injectable in-situ chemically cross-
Jingen Hu, Yang Lu, Ling Cai, Kwabena Gyabaah Owusu-Ansah, Gewen Xu, Feilong Han, Junjie Bao, Xiangjin Lin, Yiping Huang   +8 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Resilient food solutions to prevent mass famine during a nuclear winter in Argentina

Revista de Estudios Latinoamericanos sobre Reducción del Riesgo de Desastres
A nuclear war, a volcanic eruption, or the impact of an asteroid or comet can reduce the amount of sunlight reaching the Earth's surface, upon which the global food system depends.
Mónica A. Ulloa Ruiz, Jorge A. Torres Celis, Juan B. García Martínez, Morgan Rivers, David C. Denkenberger   +4 more
doaj   +1 more source

Co-evolution and networks adaptation. [PDF]

What is the role of co-evolution in the adaptation of a population of firms to a hostile environment ? To answer this question, we revisit network sociology starting from Kauffman s biological computer model.
Cartier, Manuel, Colovic, Ana
core  

An economic cross-diffusion mutualistic model for cities emergence

, 2019
We study an evolution cross-diffusion problem with mutualistic Lotka-Volterra reaction term to modelize the long-term spatial distribution of labor and capital. The mutualistic behavior is deduced from the gradient flow associated to profits maximization.
de-Córdoba, Gonzalo F., Galiano, Gonzalo   +1 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Influence of distance habitat, and memory on animal relocation patterns

, 2006
Animal movement paths are the result of a confluence of pattern-generating forces. Numerous hypotheses relate animal relocation patterns to one factor, but interactions among variables have seldom been examined, nor have a cosmopolitan host of such models been allowed to compete on common ground.
openaire   +1 more source

Novel Bio-Logging Tool for Studying Fine-Scale Behaviors of Marine Turtles in Response to Sound

, 2017
Increases in the spatial scale and intensity of activities that produce marine anthropogenic sound highlight the importance of understanding the impacts and effects of sound on threatened species such as marine turtles.
Domit, Camila, Fuentes, Mariana M. P. B., Hall, Michael, Mann, David, Nowacek, Douglas P., Piniak, Wendy Dow, Tyson, Reny B.   +6 more
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source