Results 91 to 100 of about 1,553,124 (264)

EL PROBLEMA DE LA SOSTENIBILIDAD DENTRO DE LA COMPLEJIDAD DE LOS SISTEMAS DE PRODUCCION AGROPECUARIOS THE PROBLEM OF SUSTAINABILITY WITHIN THE COMPLEXITY OF AGRICULTURAL PRODUCTION SYSTEMS

open access: yesRevista Facultad Nacional de Agronomía Medellín, 2005
El problema de la sostenibilidad es una temática que desde finales del siglo XX, ha venido preocupando cada vez mas a los diferentes sectores de la sociedad; pasando a ser uno de los temas de mayor interés para empresarios, consumidores, académicos e ...
Alejandro Cotes Torres   +1 more
doaj  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Sistemas forrageiros no semiárido do Estado do Ceará: tipologia estrutural = Forage systems in the semiarid of Ceará State: structural typology

open access: yesActa Scientiarum: Animal Sciences, 2010
Objetivou-se estabelecer a tipologia estrutural dos sistemas forrageiros (SIFs) em 57 unidades de produção rural cearenses localizadas no semiárido. Dezoito variáveis sobre utilização de superfícies, unidades e cargas animais, instalações e mão-de-obra ...
Déa de Lima Vidal
doaj  

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Editorial: First Issue

open access: yesAnimal, 2007
‘ANIMAL – An International Journal of Animal Bioscience’ is the central element in a new and exciting collaborative venture between the European Federation for Animal Science (EAAP), Institut National de la Recherche Agronomique (INRA), and British ...
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

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