Results 111 to 120 of about 809,866 (309)
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
STopTox: An in Silico Alternative to Animal Testing for Acute Systemic and Topical Toxicity. [PDF]
Environ Health Perspect, 2022 Borba JVB +13 more
europepmc +1 more source
Foodborne disease surveillance needs in Australia: Harmonisation of molecular laboratory testing and sharing data from human, animal, and food sources [PDF]
, 2004 Martyn Kirk +68 more
openalex +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Replacement of animal testing by integrated approaches to testing and assessment (IATA): a call for in vivitrosi. [PDF]
Arch Toxicol, 2022 Caloni F, De Angelis I, Hartung T.
europepmc +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Organ chips, organoids and the animal testing conundrum. [PDF]
Nat Rev Mater, 2021 Horejs C.
europepmc +1 more source