Results 131 to 140 of about 809,866 (309)

Identifying Key Factors for Accelerating the Transition to Animal-Testing-Free Medical Science through Co-Creative, Interdisciplinary Learning between Students and Teachers. [PDF]

Animals (Basel), 2022
Abarkan FZ, Wijen AMA, van Eijden RMG, Struijs F, Dennis P, Ritskes-Hoitinga M, Visseren-Hamakers I.   +6 more
europepmc   +1 more source

DIFFERENTIAL REINFORCEMENT OF ALTERNATIVE BEHAVIOR INCREASES RESISTANCE TO EXTINCTION: CLINICAL DEMONSTRATION, ANIMAL MODELING, AND CLINICAL TEST OF ONE SOLUTION [PDF]

, 2010
F. Charles Mace, Jennifer J. McComas, Benjamin C. Mauro, Patrick R. Progar, Bridget A. Taylor, Ruth A. Ervin, Amanda N. Zangrillo   +6 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Potency Testing of Venoms and Antivenoms in Embryonated Eggs: An Ethical Alternative to Animal Testing. [PDF]

Toxins (Basel), 2021
Verity EE, Stewart K, Vandenberg K, Ong C, Rockman S.   +4 more
europepmc   +1 more source

III. Animal behaviour testing: memory [PDF]

British Journal of Anaesthesia, 2014
S, Savage, D, Ma
openaire   +2 more sources

Review for "Permutation tests for hypothesis testing with animal social network data: Problems and potential solutions"

, 2021

openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Public perception of laboratory animal testing: Historical, philosophical, and ethical view. [PDF]

Addict Biol, 2021
Petetta F, Ciccocioppo R.
europepmc   +1 more source

The colony assay in-vitro as a procedure to reduce animal testing in the development of new anticancer drugs [PDF]

, 1986
H.H. Fiebig, J. Schmid
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source