Results 151 to 160 of about 809,866 (309)

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Beyond animal testing: An integrated framework for modern chemical hazard identification and risk assessment. [PDF]

Environ Sci Ecotechnol
Fan T, Yan Z, Feng C, Wu F.
europepmc   +1 more source

Advancing Vaccine Development: The Role of In Vitro Models and Progress in Reducing Animal Testing

Mehtap Tuğba Dokumacı, Semra Soydam
openalex   +2 more sources

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Antibody-based alternatives to animal testing for toxin detection and antitoxin evaluation. [PDF]

Front Toxicol
Chang SH, Jang J, Yang W, Lee NK, Choi S, Jung HI, Kim W, Cha B, Yoon SJ, Noh JY, Lee J.   +10 more
europepmc   +1 more source

Advances in Non-Animal Testing Approaches towards Accelerated Clinical Translation of Novel Nanotheranostic Therapeutics for Central Nervous System Disorders. [PDF]

Nanomaterials (Basel), 2021
Lynch MJ, Gobbo OL.
europepmc   +1 more source

Animal Testing Alternative [PDF]

, 2020
openaire   +1 more source

Nucleic Acid Test to Diagnose Cryptosporidiosis: Lab Assessment in Animal and Patient Specimens

, 2014
Zachary Crannell, Alejandro Castellanos-González, Ayesha Irani, Brittany A. Rohrman, A. Clinton White, Rebecca Richards‐Kortum   +5 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Can alternatives to animal testing yield useful information regarding biological mechanisms and drug discovery? [PDF]

J Orthop Translat
Gao Q, Chow SK, Shinohara I, Murayama M, Susuki Y, Morita M, Ma C, Goodman SB.   +7 more
europepmc   +1 more source