Results 211 to 220 of about 809,866 (309)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Testing 1,2,3: Behind The Scenes at UM Animal Labs

, 2009
Alka Chandna
openalex   +1 more source

“Play it Again”: a new method for testing metacognition in animals

, 2011
Allison L. Foote, Jonathon D. Crystal
openalex   +2 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Reducing the need for animal testing while increasing efficiency in a pesticide regulatory setting: Lessons from the EPA Office of Pesticide Programs' Hazard and Science Policy Council. [PDF]

Regul Toxicol Pharmacol, 2019
Craig E, Lowe K, Akerman G, Dawson J, May B, Reaves E, Lowit A.   +6 more
europepmc   +1 more source

Screening methods for the detection of antibiotic residues in slaughter animals: comparison of the European Union Four-Plate Test, the Nouws Antibiotic Test and the Premi®Test (applied to muscle and kidney)

, 2010
M.G. Pikkemaat, Michel Rapallini, T. Zuidema, J.W. Alexander Elferink, S. Oostra-van Dijk, W.D.M. Driessen-van Lankveld   +5 more
openalex   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

FDA-approved drugs that are spermatotoxic in animals and the utility of animal testing for human risk prediction. [PDF]

J Assist Reprod Genet, 2018
Rayburn ER, Gao L, Ding J, Ding H, Shao J, Li H.   +5 more
europepmc   +1 more source

Alternatives in animal testing. [PDF]

Environmental Health Perspectives, 1996
openaire   +1 more source

A soluble antigen fluorescent antibody (SAFA) test for the immunodiagnosis of trichinellosis in man and experimental animals.

, 1970
R.W. Gore, E. H. Sadun
openalex   +1 more source