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TRADITIONAL ANIMAL SCREENING TESTS
Acta Endocrinologica, 1974ABSTRACT It is fundamental that before new chemicals may enter the environment of man, they should seem to be (i) desirable and (ii) reasonably safe. Although new chemicals should be treated as separate entities, there is little evidence in general terms to suggest that there is an alternative to screening tests in intact animals, despite the ...
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Assessing tests of animal consciousness
Consciousness and Cognition, 2022Which animals have conscious experiences? Many different, diverse and unrelated behaviors and cognitive capacities have been proposed as tests of the presence of consciousness in an animal. It is unclear which of these tests, if any, are valid. To remedy this problem, I develop a list consisting of eight desiderata which can be used to assess putative ...
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Chemical & Engineering News Archive, 2007
TESTING CHEMICALS on animals for human toxicity should be greatly reduced and can potentially be eliminated in favor of experiments using cells, cell lines, or cellular components, says a National Research Council report released last week. Advances in systems biology and methods to test cells and tissues are fundamentally changing the way scientists ...
CHERYL HOGUE, JEFF JOHNSON
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TESTING CHEMICALS on animals for human toxicity should be greatly reduced and can potentially be eliminated in favor of experiments using cells, cell lines, or cellular components, says a National Research Council report released last week. Advances in systems biology and methods to test cells and tissues are fundamentally changing the way scientists ...
CHERYL HOGUE, JEFF JOHNSON
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Beyond Animal Testing Index: Benchmarking tool for a world beyond animal testing [PDF]
ALTEXWhile the original definition of replacement focuses on the replacement of the use of animals in science, a more contemporary definition focuses on accelerating the development and use of predictive and robust models, based on the latest science and technologies, to address scientific questions without the use of animals.
Krul, C. +5 more
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Science News, 1966
0 ANIMALS have been used and abused by man for all manner of reasons, since the first erect human took a club and cracked the skull of some stray creature for food. They have been eaten, turned into clothing, used as motor vehicles and worked as tools. Most recently, they have substituted for man in the laboratory.
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0 ANIMALS have been used and abused by man for all manner of reasons, since the first erect human took a club and cracked the skull of some stray creature for food. They have been eaten, turned into clothing, used as motor vehicles and worked as tools. Most recently, they have substituted for man in the laboratory.
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Are Animal Tests Inherently Valid?
Alternatives to Laboratory Animals, 2004The proposition that animal tests are inherently valid, merely because they are animal tests, is discussed and is rejected. It is concluded that there is no justifiable reason for subjecting new or substantially modified animal test procedures or testing strategies to a validation process that is any less stringent than that applied to non-animal ...
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Pulmonary Function Testing in Animals
2018Nanoparticles possess a number of useful properties that make them useful for a variety of industrial and commercial applications. The small size of nanoparticles means that they are respirable and can penetrate deep into the lung when inhaled. Because of this, there is interest in assessing possible toxic effects of nanoparticles on the respiratory ...
Gary W, Hoyle +2 more
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The Replacement of Animal Tests
Alternatives to Laboratory Animals, 2018Progress toward the acceptance and application of validated alternative test methods as replacements for animal tests, is being frustrated by the unsatisfactory procedures involved in approving new test guidelines and deleting existing ones
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Mutational Spectrometry In Animal Toxicity Testing
Annual Review of Pharmacology and Toxicology, 1990The microbial geneticists who pioneered the study of mutational spectra have shown us how rich a source of mutagen-specific information it can be for the pharmacologist and toxicologist. Contributions by physical chemists and molecular biologists have led to a practical means to observe mutation spectra directly from the DNA of cultured human cells and
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