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An Anglocentric History of Anaesthetics and Analgesics in the Refinement of Animal Experiments
Animals, 2020 Previous histories of animal experimentation, e.g., Franco (2013) have focused on ethics, the law and the personalities involved, but not on the involvement of anaesthetics or analgesics. Given that these were major subjects of (UK) Parliamentary debates
R. Eddie Clutton
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Animals, 2022 The present study focused on an in-depth analysis of adolescents’ (aged 15–16) attitudes towards animal experimentation. Focus group interviews were conducted to gain a deeper understanding regarding the ethical considerations of this age group. The data
Sonja M. Enzinger, Christian Dürnberger
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Genetic parameters for milk mineral content and acidity predicted by mid-infrared spectroscopy in Holstein–Friesian cows [PDF]
, 2015 peer-reviewedThis article was first published in animal, Volume 9, Issue 05, May 2015, pp 775-780 © The Animal Consortium 2015The aim of the present study was to estimate genetic parameters for calcium (Ca), phosphorus (P) and titratable acidity (TA) in ...
Berry, Donagh +5 more
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Immunocompetent murine models for the study of glioblastoma immunotherapy. [PDF]
, 2014 Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in ...
Bloch, Orin +9 more
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Incorporation of a tetrameric M2e antigen enhances cross-protective efficacy of an inactivated H5N1 avian influenza vaccine [PDF]
BIO Web of ConferencesAvian influenza (AI) viruses continuously undergo genetic mutations that reduce vaccine efficacy and allow outbreaks to persist. The ectodomain of the M2 protein (M2e) is highly conserved among AI viruses, making it a promising universal vaccine ...
Pertela Gian +8 more
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Functionally Annotating Regulatory Elements in the Equine Genome Using Histone Mark ChIP-Seq. [PDF]
, 2019 One of the primary aims of the Functional Annotation of ANimal Genomes (FAANG) initiative is to characterize tissue-specific regulation within animal genomes.
Bellone, Rebecca R +9 more
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Počki, 2018 Background. In our previous study (message 1), a comparative evaluation on the efficacy of two uricodepressants, allopurinol and febuxostat, was performed in terms of their effect on the functional state of the kidneys in patients with gouty nephropathy,
O.V. Sinyachenko +2 more
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Applying the adverse outcome pathway (AOP) for food sensitization to support in vitro testing strategies [PDF]
, 2019 Background Before introducing proteins from new or alternative dietary sources into the market, a compressive risk assessment including food allergic sensitization should be carried out in order to ensure their safety.
Benedé, Sara +14 more
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A neutralizing antibody protects Kunming mice against AKAV lethal challenge
BMC Veterinary ResearchBackground Akabane virus (AKAV) infection is associated with arthrogryposis-hydranencephaly syndrome in ruminants. Current commercialized AKAV live attenuated vaccines have safety concerns and cannot fully protect against all genotypes or emerging ...
Jingjing Wang +6 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background The HIT network was established in 2000 to create a population‐based structure aiming to improve survival rates and reduce late effects for children with central nervous system (CNS) tumors by conducting comprehensive clinical trials.
Stefan Rutkowski +59 more
wiley +1 more source