Results 51 to 60 of about 1,812,118 (303)

Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury

Frontiers in Drug Discovery
Predicting which drugs might have the potential to cause drug-induced liver injury (DILI) is highly complex and the current methods, 2D cell-based models and animal tests, are not sensitive enough to prevent some costly failures in clinical trials or to ...
K. Taylor, R. Ram, R. Ram, L. Ewart, C. Goldring, G. Russomanno, G. P. Aithal, T. Kostrzewski, C. Bauch, J. M. Wilkinson, J. M. Wilkinson, S. Modi, J. G. Kenna, J. G. Kenna, J. Bailey, J. Bailey   +15 more
doaj   +1 more source

Laparoscopic Assisted Fusion of the Lumbosacral Spine: A Biomechanical and Histologic Analysis of the Open Versus Laparoscopic Technique in an Animal Model [PDF]

, 1997
Study Design. An animal model for laparoscopic lumbosacral fusion. Objectives. To compare the biomechanical and histologic results of open to laparoscopic lumbosacral discectomy and fusion in an animal model. Background Data.
Cahn, Nguyen, Eck, Jason C., Lim, Tae Hong, McGrady, Linda M., Riley, Lee H., III, Toth, Jeffrey M., Yoshida, Hiryuki   +6 more
core   +1 more source

Toxoplasma gondii Infection in Animal-Friendly Pig Production Systems [PDF]

, 2004
PURPOSE. Consumption of undercooked pork meat products has been considered a major risk factor for contracting toxoplasmosis in humans. Indoor farming and improved hygiene have drastically reduced Toxoplasma infections in pigs over the past decades ...
Cornelissen, Jan, Eijck, Ineke, Eissen, Okke A., Kijlstra, Aize, Kortbeek, Titia, Munniksma, Klaske   +5 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Regulation and Safety of Cosmetics: Pre- and Post-Market Considerations for Adverse Events and Environmental Impacts

Cosmetics
Cosmetic products have been increasingly regulated, particularly in Europe. With the introduction of the cosmetic regulation in 2013, stricter quality standards were implemented, surpassing those set by the 1976 legislation.
Daniela Vieira, Joana Duarte, Pedro Vieira, Maria Beatriz S. Gonçalves, Ana Figueiras, Alka Lohani, Francisco Veiga, Filipa Mascarenhas-Melo   +7 more
doaj   +1 more source

Similarities and Differences in Gene Expression Networks Between the Breast Cancer Cell Line Michigan Cancer Foundation-7 and Invasive Human Breast Cancer Tissues

Frontiers in Artificial Intelligence, 2021
Failure to adequately characterize cell lines, and understand the differences between in vitro and in vivo biology, can have serious consequences on the translatability of in vitro scientific studies to human clinical trials.
Vy Tran, Robert Kim, Mikhail Maertens, Thomas Hartung, Thomas Hartung, Thomas Hartung, Alexandra Maertens   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory

Communications Biology
Brain Microphysiological Systems, including neural organoids derived from human induced pluripotent stem cells, offer a unique lens to study the intricate workings of the human brain.
Dowlette-Mary Alam El Din, Leah Moenkemoeller, Alon Loeffler, Forough Habibollahi, Jack Schenkman, Amitav Mitra, Tjitse van der Molen, Lixuan Ding, Jason Laird, Maren Schenke, Erik C. Johnson, Brett J. Kagan, Thomas Hartung, Lena Smirnova   +13 more
doaj   +1 more source

An analysis of trends in the use of animal and non-animal methods in biomedical research and toxicology publications

Frontiers in Lab on a Chip Technologies
IntroductionThere have been relatively few attempts to quantitatively assess if, and in which areas, the use of non-animal methods (NAMs) is increasing in biomedical research and importantly, how this compares to the use of live animals.MethodsWe ...
Katy Taylor, Stephanie Modi, Jarrod Bailey   +2 more
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source