Results 61 to 70 of about 809,866 (309)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A novel spine tester TO GO

JOR Spine
Background Often after large animal experiments in spinal research, the question arises—histology or biomechanics? While biomechanics are essential for informed decisions on the functionality of the therapy being studied, scientists often choose ...
Jan Ulrich Jansen, Laura Zengerle, Marcel Steiner, Vincenza Sciortino, Marianna Tryfonidou, Hans‐Joachim Wilke   +5 more
doaj   +1 more source

In Vivo Testing of a Second-Generation Prototype Accessory for Single Transapical Left Ventricular Assist Device Implantation

Bioengineering
A new accessory was developed to allow implantation of left ventricular assist devices (LVADs) without requiring an anastomosis to the ascending aorta. The accessory combines the LVAD inflow and outflow into a dual-lumen device.
Florian Meissner, Michelle Costa Galbas, Hendrik Straky, Heiko Vestner, Manuela Schoen, Marius Schimmel, Johanna Reuter, Martin Buechsel, Johannes Dinkelaker, Heidi Cristina Schmitz, Martin Czerny, Wolfgang Bothe   +11 more
doaj   +1 more source

Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery

Particle and Fibre Toxicology, 2019
Background The blood brain barrier (BBB) is the bottleneck of brain-targeted drug development. Due to their physico-chemical properties, nanoparticles (NP) can cross the BBB and accumulate in different areas of the central nervous system (CNS), thus are ...
Paulo Emílio Corrêa Leite, Mariana Rodrigues Pereira, Georgina Harris, David Pamies, Lisia Maria Gobbo dos Santos, José Mauro Granjeiro, Helena T. Hogberg, Thomas Hartung, Lena Smirnova   +8 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Ethics and artificiality

Inscriptions, 2018
This essay interrogates the place of ethics, which needs to be located  in philosophy alongside studies of being. Ethics is not an omniscient field of study: there is a room outside ethics, and yet there is ethics.
Wolfgang Schirmacher, Daniel Theisen
doaj  

Critical Appraisal of Exposure Studies of E-Cigarette Aerosol Generated by High-Powered Devices*

Contributions to Tobacco and Nicotine Research
Currently low-powered pods and disposables overwhelmingly dominate consumer preference of vaping products. Yet, despite its marginal usage, third generation high power low resistance (sub-ohm) devices are still used frequently to generate aerosols for ...
Soulet Sébastien, Sussmann Roberto A.
doaj   +1 more source

The potential of diagnostic point‐of‐care tests (POCTs) for infectious and zoonotic animal diseases in developing countries: Technical, regulatory and sociocultural considerations [PDF]

, 2020
Emma C. Hobbs, Axel Colling, Ratna B. Gurung, John Allen   +3 more
openalex   +1 more source