Results 81 to 90 of about 1,812,118 (303)

Ethical and Legal Implications of Animal Use in Didactic Situations: The Conceptions of undergraduate Biology and Biomedicine students of a Federal Institution of Higher Education located in the State of Rio de Janeiro – Brazil [PDF]

open access: yesInvestigações em Ensino de Ciências, 2011
The use of animals in teaching situations is one of the methods of animal experimentation that has been institutionalized in the scientific context of the eighteenth century, when it was believed that animals had no soul or feel pain.
Izabel Christina Pitta P. de S. Melgaço   +2 more
doaj  

Weighted Gene Correlation Network Analysis (WGCNA) Reveals Novel Transcription Factors Associated With Bisphenol A Dose-Response

open access: yesFrontiers in Genetics, 2018
Despite Bisphenol-A (BPA) being subject to extensive study, a thorough understanding of molecular mechanism remains elusive. Here we show that using weighted gene correlation network analysis (WGCNA), which takes advantage of a graph theoretical approach
Alexandra Maertens   +5 more
doaj   +1 more source

The Historical Development of Animal Toxicity Testing [PDF]

open access: yes, 2012
This paper traces the historical development of animal toxicity testing, from its ancient origins through the period of standardization following World War II.
Gertler, N.
core  

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Critical Appraisal of Exposure Studies of E-Cigarette Aerosol Generated by High-Powered Devices*

open access: yesContributions to Tobacco and Nicotine Research
Currently low-powered pods and disposables overwhelmingly dominate consumer preference of vaping products. Yet, despite its marginal usage, third generation high power low resistance (sub-ohm) devices are still used frequently to generate aerosols for ...
Soulet Sébastien, Sussmann Roberto A.
doaj   +1 more source

Coagulase gene polymorphism, enterotoxigenecity, biofilm production, and antibiotic resistance in Staphylococcus aureus isolated from bovine raw milk in North West India

open access: yesAnnals of Clinical Microbiology and Antimicrobials, 2017
Background Staphylococcus aureus is the predominant bacterium responsible for various diseases in animals and humans. Preventive strategies could be better implemented by understanding the prevalence, genetic patterns, and the presence of enterotoxin and
Vishnu Sharma   +5 more
doaj   +1 more source

Multicentric B-cell lymphoma in a pygmy goat [PDF]

open access: yes, 2016
A six-year-old, male pygmy goat was referred with a sudden onset of peripheral lymphadenopathy, which initially started as enlarged inguinal lymph nodes. Clinical examination showed swollen retropharyngeal, prescapular and inguinal lymph nodes. Serologic
Chiers, Koen   +6 more
core  

Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae [PDF]

open access: yes, 2013
Trichuriasis represents a major public health problem in the developing world and is regarded as a neglected disease. Albendazole and mebendazole, the two drugs of choice against trichuriasis display only moderate cure rates, hence alternative drugs are ...
Keiser, Jennifer   +2 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Documentation for the spatial analysis system (SPAN) for resource use by animals [PDF]

open access: yes, 1986
Nearest-neighbor analyses have been used with mapped data f or tests of spatial dispersion and association i n plant and animal ecology. This paper full describes a computer software package developed to use Monte Carlo trials instead of chi-squared ...
Lindberg, William J., McElroy, David A.
core  

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