Results 81 to 90 of about 1,698,103 (349)

Progress Toward Replacing Animals in Toxicity Testing for Cosmetics [PDF]

, 2012
In the 1980’s, animal rights activists successfully motivated the cosmetic industry to begin researching alternatives to animal tests.
Nye, Marisa B.
core  

Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans [PDF]

, 2015
Although the process of drug development requires efficacy and toxicity testing in animals prior to human testing, animal models have limited ability to accurately predict human responses to xenobiotics and other insults.
Bakan, Ahmet, Bale, Shyam S, Berk Usta, O, Bhushan, Abhinav, Biasio, Richard, Golberg, Inna, Gough, Albert, Hegde, Manjunath, Jindal, Rohit, Lansing Taylor, D, McCarty, William J, Senutovitch, Nina, Shun, Tong Ying, Vernetti, Lawrence, Yarmush, Martin L   +14 more
core   +1 more source

Analysis on the Difference of Mineral Element Content in Yak Meat

Shipin gongye ke-ji
Objective: Analyze the differences in mineral element content in yak meat from Leiwuqi County, Changdu City, Tibet. Methods: This study focused on 431 yak meat samples from Leiwuqi County, Xizangchang City, including (Kamado Township, Leiwuqi Township ...
Xiaojun YANG, Tangwei ZHANG, Rendeji CI, Yifan ZHANG, Xuelian WU   +4 more
doaj   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Screening vaccine formulations for biological activity using fresh human whole blood. [PDF]

, 2014
Understanding the relevant biological activity of any pharmaceutical formulation destined for human use is crucial. For vaccine-based formulations, activity must reflect the expected immune response, while for non-vaccine therapeutic agents, such as ...
Aboutorabian, Sepideh, Ausar, Salvador F, Brookes, Roger H, Dockrell, Hazel M, Ha, Yukyung, Hakimi, Jalil, Hasija, Manvi, Rahman, Nausheen, Smith, Steven G, Todryk, Stephen M   +9 more
core   +1 more source

Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery

Particle and Fibre Toxicology, 2019
Background The blood brain barrier (BBB) is the bottleneck of brain-targeted drug development. Due to their physico-chemical properties, nanoparticles (NP) can cross the BBB and accumulate in different areas of the central nervous system (CNS), thus are ...
Paulo Emílio Corrêa Leite, Mariana Rodrigues Pereira, Georgina Harris, David Pamies, Lisia Maria Gobbo dos Santos, José Mauro Granjeiro, Helena T. Hogberg, Thomas Hartung, Lena Smirnova   +8 more
doaj   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Monitoring wild animal communities with arrays of motion sensitive camera traps [PDF]

, 2010
Studying animal movement and distribution is of critical importance to addressing environmental challenges including invasive species, infectious diseases, climate and land-use change.
Carbone, Chris, Eggert, Jay, Fountain, Tony, He, Zhihai, Jansen, Patrick A., Kays, Roland, Kranstauber, Bart, Rowcliffe, Marcus J., Tilak, Sameer   +8 more
core   +1 more source

In Vivo Testing of a Second-Generation Prototype Accessory for Single Transapical Left Ventricular Assist Device Implantation

Bioengineering
A new accessory was developed to allow implantation of left ventricular assist devices (LVADs) without requiring an anastomosis to the ascending aorta. The accessory combines the LVAD inflow and outflow into a dual-lumen device.
Florian Meissner, Michelle Costa Galbas, Hendrik Straky, Heiko Vestner, Manuela Schoen, Marius Schimmel, Johanna Reuter, Martin Buechsel, Johannes Dinkelaker, Heidi Cristina Schmitz, Martin Czerny, Wolfgang Bothe   +11 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source