Results 131 to 140 of about 282,052 (348)

STopTox: An in Silico Alternative to Animal Testing for Acute Systemic and Topical Toxicity

open access: diamond, 2022
Joyce Villa Verde Bastos Borba   +13 more
openalex   +1 more source

[Legal aspects of alternative methods to animal testing].

open access: yesBiologie aujourd'hui, 2023
Si le remplacement total de l’expérimentation animale était l’objectif visé par la directive européenne du 22 septembre 2010 relative à la protection des animaux utilisés à des fins scientifiques, force est de constater qu’il est encore loin d’être atteint. Le nombre d’animaux ne diminue pas et les méthodes alternatives peinent à être utilisées.
openaire   +2 more sources

POLICY options [PDF]

open access: yes, 2009
End of project reportThe incomes of Irish cattle farmers benefited greatly from the reform of the CAP for beef and cereals in 1992 and more recently under Agenda 2000.
Dunne, William   +2 more
core  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

MODELING THE COSTS OF FOOD SAFETY REGULATION [PDF]

open access: yes
Food safety, regulatory costs, cost/benefit analysis, Food Consumption/Nutrition/Food Safety,
Crutchfield, Stephen R.   +1 more
core   +1 more source

The Failure of Federal Biotechnology Regulation [PDF]

open access: yes, 2017
The recent court case and state ballot measures regarding mandatory labels for Genetically Modified Organisms (“GMOs”) suggest the need for a deeper conversation about the federal framework for regulating biotechnology.
Peck, Alison
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

The 2002 Farm Bill: Revitalizing the Farm Economy Through Renewable Energy Development [PDF]

open access: yes, 2001
2002 Policy Report.Reduced profit margins and low commodity prices have forced many to leave farming in the past decade, or rely increasingly on off-farm income, while more attractive opportunities in less volatile industries have deterred many young ...
Carol Werner, Jeremy Ames
core  

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

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