Results 131 to 140 of about 923,548 (275)

State of the art on alternative methods to animal testing from an industrial point of view: Ready for regulation?

, 2014
Rachel Ashton
openalex   +3 more sources

Advancing skin model development: A focus on a self-assembled, induced pluripotent stem cell-derived, xeno-free approach

Journal of Tissue Engineering
The demand for skin models as alternatives to animal testing has grown due to ethical concerns and the need for accurate substance evaluation. These alternatives, known as New Approach Methodologies (NAMs), are increasingly used for regulatory decisions.
Marla Dubau, Tarada Tripetchr, Lava Mahmoud, Vivian Kral, Burkhard Kleuser   +4 more
doaj   +1 more source

Alternatives to animal use in research, testing, and education

, 1986

openalex   +2 more sources

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

VALIDACIÓN INTRALABORATORIO DE UNA METODOLOGÍA ANALÍTICA POR ESPECTROFOTOMETRÍA UV/VIS PARA EVALUAR EL POTENCIAL IRRITANTE OCULAR DE TENSOACTIVOS EN GLÓBULOS ROJOS INTRALABORATORY VALIDATION OF AN ANALYTICAL METHODOLOGY BY UV/VIS SPECTROMETRY IN ORDER TO EVALUATE THE OCULAR IRRITANT POTENTIAL OF TENSOACTIVES IN RED BLOOD CELLS

Vitae, 2011
Se presentan los resultados de la validación intralaboratorio para los parámetros de linealidad, repetibilidad y precisión intermedia del ensayo en glóbulos rojos, metodología in vitro empleada para evaluar la irritación ocular.
Luz A LEGUIZAMÓN B, Ever A HERRERA C, Jorge A MARTÍNEZ R, María C LOZANO A   +3 more
doaj  

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Implementation of the 3Rs Concept in Quality Control of Biologicals: Status and Prospects (Review)

Безопасность и риск фармакотерапии
INTRODUCTION. Many countries are implementing an increasing number of alternatives to animal testing in the research, development, and quality control of medicines under the concept of 3Rs (replacement, reduction, and refinement).
L. A. Gaiderova, N. A. Alpatova, O. V. Golovinskaya, A. M. Guskov, E. K. Lipatova, M. N. Lavrova   +5 more
doaj   +1 more source

Chemosensitivity Test Using Collagen-Gel Droplet Embedded Culture Method(CD-DST). A Practical Clinical Usefulness and Possibility for Alternative to Animal Experiment.

, 1997
Hisayuki KOBAYASHI, Keizo Tanisaka, Kazuhiko Minamigawa, Yoshiko MITO, Makoto Inaba   +4 more
openalex   +2 more sources

No alternative to animal tests for behaviour [PDF]

Nature, 2002
openaire   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source