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Alternatives to animal testing: A review [PDF]
Saudi Pharmaceutical Journal, 2015 The number of animals used in research has increased with the advancement of research and development in medical technology. Every year, millions of experimental animals are used all over the world. The pain, distress and death experienced by the animals during scientific experiments have been a debating issue for a long time. Besides the major concern
Doke SK, Dhawale SC.
exaly +4 more sources
Alternatives to animal testing to assess MASH drugs and hepatotoxicity. [PDF]
Hepatology, 2023 The Food and Drug Administration (FDA) Modernization Act 2.0 “allows for alternatives to animal testing for purposes of drug and biological product applications.” This provides an opportunity to develop and improve alternatives to animal studies to assess drugs in the liver.
Brenner DA, Brenner DA.
europepmc +3 more sources
Multiparametric Material Functionality of Microtissue‐Based In Vitro Models as Alternatives to Animal Testing [PDF]
Advanced Science, 2022 With the definition of the 3R principle by Russel and Burch in 1959, the search for an adequate substitute for animal testing has become one of the most important tasks and challenges of this time, not only from an ethical, but also from a scientific ...
Elena Stengelin +2 more
doaj +2 more sources
Towards learning and memory risk assessment with human brain organoids: barriers and opportunities [PDF]
Frontiers in ToxicologyNeurodevelopmental conditions, including autism spectrum disorder, intellectual disability, and learning disabilities, as well as neurodegenerative disorders, affect millions of people in the United States alone.
Ronit Mohapatra +6 more
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Antibody-based alternatives to animal testing for toxin detection and antitoxin evaluation [PDF]
Frontiers in ToxicologyAnimal experiments have long played a central role in biomedical research and toxicology, yet their limitations in translational accuracy and ethical concerns have intensified the demand for reliable alternatives.
Seo-Hyuk Chang +17 more
doaj +2 more sources
Can alternatives to animal testing yield useful information regarding biological mechanisms and drug discovery? [PDF]
Journal of Orthopaedic TranslationEstablish alternative strategies to standard animal experiments decrease animal utilization and simultaneously enhance the reliability of biological and disease models.
Qi Gao +7 more
doaj +2 more sources
Alternatives to Animal Testing [PDF]
Journal of Toxicology: Cutaneous and Ocular Toxicology, 2019 Animal experimentation has long been a controversial issue with impassioned arguments on both sides of the debate. Increasingly it has become more expedient and feasible to develop new methods that avoid the use of animals. There is agreement on both sides that reduction and refinement of experiments on animals should be an important goal for the ...
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Frontiers in Toxicology, 2023 Introduction: The positive identification of xenobiotics and their metabolites in human biosamples is an integral aspect of exposomics research, yet challenges in compound annotation and identification continue to limit the feasibility of comprehensive ...
Breanne Kincaid +6 more
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Frontiers in Artificial Intelligence, 2021 Failure to adequately characterize cell lines, and understand the differences between in vitro and in vivo biology, can have serious consequences on the translatability of in vitro scientific studies to human clinical trials.
Vy Tran +6 more
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Frontiers in Cellular Neuroscience, 2023 IntroductionOligodendrocytes (OLs) are the myelin-forming cells of the central nervous system (CNS). Although OLs can be differentiated from human-induced pluripotent stem cells (hiPSCs), the in vitro modeling of axon myelination in human cells remains ...
July Carolina Romero +6 more
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