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Alternatives to animal testing: A review [PDF]
Saudi Pharmaceutical Journal, 2015 The number of animals used in research has increased with the advancement of research and development in medical technology. Every year, millions of experimental animals are used all over the world. The pain, distress and death experienced by the animals during scientific experiments have been a debating issue for a long time. Besides the major concern
Doke SK, Dhawale SC.
exaly +4 more sources
Antibody-based alternatives to animal testing for toxin detection and antitoxin evaluation [PDF]
Frontiers in ToxicologyAnimal experiments have long played a central role in biomedical research and toxicology, yet their limitations in translational accuracy and ethical concerns have intensified the demand for reliable alternatives.
Seo-Hyuk Chang +17 more
doaj +4 more sources
Alternatives to animal testing to assess MASH drugs and hepatotoxicity. [PDF]
Hepatology, 2023 The Food and Drug Administration (FDA) Modernization Act 2.0 “allows for alternatives to animal testing for purposes of drug and biological product applications.” This provides an opportunity to develop and improve alternatives to animal studies to assess drugs in the liver.
Brenner DA, Brenner DA.
europepmc +3 more sources
Towards learning and memory risk assessment with human brain organoids: barriers and opportunities [PDF]
Frontiers in ToxicologyNeurodevelopmental conditions, including autism spectrum disorder, intellectual disability, and learning disabilities, as well as neurodegenerative disorders, affect millions of people in the United States alone.
Ronit Mohapatra +6 more
doaj +2 more sources
Alternatives to Animal Testing [PDF]
Journal of Toxicology: Cutaneous and Ocular Toxicology, 1994 (1996). Alternatives to Animal Testing. Journal of Toxicology: Cutaneous and Ocular Toxicology: Vol. 15, No. 1, pp. 29-31.
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Frontiers in Toxicology, 2023 Introduction: The positive identification of xenobiotics and their metabolites in human biosamples is an integral aspect of exposomics research, yet challenges in compound annotation and identification continue to limit the feasibility of comprehensive ...
Breanne Kincaid +6 more
doaj +1 more source
Frontiers in Artificial Intelligence, 2021 Failure to adequately characterize cell lines, and understand the differences between in vitro and in vivo biology, can have serious consequences on the translatability of in vitro scientific studies to human clinical trials.
Vy Tran +6 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2023 IntroductionOligodendrocytes (OLs) are the myelin-forming cells of the central nervous system (CNS). Although OLs can be differentiated from human-induced pluripotent stem cells (hiPSCs), the in vitro modeling of axon myelination in human cells remains ...
July Carolina Romero +6 more
doaj +1 more source
Frontiers in Genetics, 2018 Despite Bisphenol-A (BPA) being subject to extensive study, a thorough understanding of molecular mechanism remains elusive. Here we show that using weighted gene correlation network analysis (WGCNA), which takes advantage of a graph theoretical approach
Alexandra Maertens +5 more
doaj +1 more source
Particle and Fibre Toxicology, 2019 Background The blood brain barrier (BBB) is the bottleneck of brain-targeted drug development. Due to their physico-chemical properties, nanoparticles (NP) can cross the BBB and accumulate in different areas of the central nervous system (CNS), thus are ...
Paulo Emílio Corrêa Leite +8 more
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