Results 21 to 30 of about 87,604,756 (316)
Particle and Fibre Toxicology, 2019 Background The blood brain barrier (BBB) is the bottleneck of brain-targeted drug development. Due to their physico-chemical properties, nanoparticles (NP) can cross the BBB and accumulate in different areas of the central nervous system (CNS), thus are ...
Paulo Emílio Corrêa Leite +8 more
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Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model
Frontiers in Cellular Neuroscience, 2020 Selective serotonin reuptake inhibitors (SSRIs) are frequently used to treat depression during pregnancy. Various concerns have been raised about the possible effects of these drugs on fetal development.
Xiali Zhong +15 more
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Deconvoluting gene and environment interactions to develop an “epigenetic score meter” of disease
EMBO Molecular Medicine, 2023 Human health is determined both by genetics (G) and environment (E). This is clearly illustrated in groups of individuals who are exposed to the same environmental factor showing differential responses.
Alessio Butera +6 more
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Alternatives to laboratory animals : ATLA, 2023 The decisions we make on chemical safety, for consumers, workers and the environment, must be based on the best scientific data and knowledge available. Rapid advances in biology, in cell-based technologies and assays, and in analytical and computational
J. Fentem
semanticscholar +1 more source
Artificial intelligence as the new frontier in chemical risk assessment
Frontiers in Artificial Intelligence, 2023 The rapid progress of AI impacts various areas of life, including toxicology, and promises a major role for AI in future risk assessments. Toxicology has shifted from a purely empirical science focused on observing chemical exposure outcomes to a data ...
Thomas Hartung, Thomas Hartung
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Alternatives to laboratory animals : ATLA, 2021 Animal use for testing chemicals under REACH continues to increase, despite advances in non-animal safety science during the past 15 years. The application of modern science and technology, and the use of ‘next generation’ weight-of-evidence assessment ...
J. Fentem +3 more
semanticscholar +1 more source
Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem
iScience, 2020 Summary: Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient ...
David Pamies +2 more
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A History of Regulatory Animal Testing: What Can We Learn?
Alternatives to laboratory animals : ATLA, 2022 The contemporary pharmaceutical industry is voicing growing concerns about the translatability and reproducibility of animal models. In addition, the usefulness of certain of the required regulatory safety tests in animals is being increasingly ...
Doortje Swaters +4 more
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Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres
Frontiers in Microbiology, 2018 Human induced pluripotent stem cells (iPSCs), together with 21st century cell culture methods, have the potential to better model human physiology with applications in toxicology, disease modeling, and the study of host-pathogen interactions.
Celina Monteiro Abreu +9 more
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Recent Developments in Alternatives to Animal Testing
Animal Experimentation: Working Towards a Paradigm Change, 2019 At least 115 million animals are thought to be used for scientific purposes every year, worldwide (Taylor et al., 2008). Animals are typically used to test whether an intervention will cause harm to humans or other animals of the same or different ...
Katy Taylor
semanticscholar +1 more source