Results 11 to 20 of about 87,604,756 (316)
The new paradigm in animal testing – “3Rs alternatives”
Regulatory Toxicology and PharmacologyRegulatory studies have revolutionised over time. Today, the focus has shifted from animal toxicity testing to non-animal for regulatory safety testing. This move is in line with the international 3Rs (Replacement, Reduction, and Refinement) principle and has also changed the regulator's perspective.
Wen Tsin, Poh, Johnson, Stanslas
openaire +3 more sources
Alternatives to Animal Testing in the Safety Evaluation of Products
Alternatives to Laboratory Animals, 2002 The conventional method for assessing the safety of products, ranging from pharmaceuticals to agrochemicals, biocides and industrial and household chemicals — including cosmetics — involves determining their toxicological properties by using experimental animals. The aim is to identify any possible adverse effects in humans by using these animal models.
Derek J, Knight, Damien, Breheny
openaire +3 more sources
Editorial: AI-driven scientific discovery—transforming research across disciplines [PDF]
Frontiers in Artificial IntelligenceThomas Hartung +3 more
doaj +2 more sources
FDA Modernization Act 2.0 allows for alternatives to animal testing.
Artificial Organs, 2023 On December 29, 2022, President Biden signed into law the FDA Modernization Act 2.0. The bill essentially refutes the Federal Food, Drug, and Cosmetics Act of 1938, which mandated animal testing for every new drug development protocol. While for the past
Jason J. Han
semanticscholar +1 more source
Frontiers in Toxicology, 2023 Introduction: The positive identification of xenobiotics and their metabolites in human biosamples is an integral aspect of exposomics research, yet challenges in compound annotation and identification continue to limit the feasibility of comprehensive ...
Breanne Kincaid +6 more
doaj +1 more source
Frontiers in Artificial Intelligence, 2021 Failure to adequately characterize cell lines, and understand the differences between in vitro and in vivo biology, can have serious consequences on the translatability of in vitro scientific studies to human clinical trials.
Vy Tran +6 more
doaj +1 more source
Current Strategies in Assessment of Nanotoxicity: Alternatives to In Vivo Animal Testing
International Journal of Molecular Sciences, 2021 Millions of experimental animals are widely used in the assessment of toxicological or biological effects of manufactured nanomaterials in medical technology. However, the animal consciousness has increased and become an issue for debate in recent years.
Hung-Jin Huang +5 more
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2023 IntroductionOligodendrocytes (OLs) are the myelin-forming cells of the central nervous system (CNS). Although OLs can be differentiated from human-induced pluripotent stem cells (hiPSCs), the in vitro modeling of axon myelination in human cells remains ...
July Carolina Romero +6 more
doaj +1 more source
Alternatives to laboratory animals : ATLA, 2020 Across the spectrum of industrial sectors, including pharmaceuticals, chemicals, personal care products, food additives and their associated regulatory agencies, there is a need to develop robust and reliable methods to reduce or replace animal testing ...
J. Madden, S. Enoch, A. Paini, M. Cronin
semanticscholar +1 more source
Frontiers in Genetics, 2018 Despite Bisphenol-A (BPA) being subject to extensive study, a thorough understanding of molecular mechanism remains elusive. Here we show that using weighted gene correlation network analysis (WGCNA), which takes advantage of a graph theoretical approach
Alexandra Maertens +5 more
doaj +1 more source