Results 41 to 50 of about 55,459 (256)

Metabolomics in Preclinical Drug Safety Assessment: Current Status and Future Trends

Metabolites
Metabolomics is emerging as a powerful systems biology approach for improving preclinical drug safety assessment. This review discusses current applications and future trends of metabolomics in toxicology and drug development.
Fenna Sillé, Thomas Hartung
doaj   +1 more source

In silico methods – Computational alternatives to animal testing

ALTEX, 2018
A seminar and interactive workshop on “In silico Methods – Computational Alternatives to Animal Testing” was held in Berlin, Germany, organized by Annemarie Lang, Frank Butt- gereit and Andrea Volkamer at the Charite-Universitatsmedizin Berlin, on August 17-18, 2017. During the half-day seminar, the variety and applications of in silico methods as
Lang, Annemarie, Volkamer, Andrea, Behm, Laura, Roblitz, Susanna, Ehrig, Rainald, Schneider, Marlon, Geris, Liesbet, Wichard, Joerg, Buttgereit, Frank   +8 more
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Green toxicology only becomes beautiful through AI

Frontiers in Chemistry
Green Toxicology extends the principles of Green Chemistry by embedding toxicological foresight into chemical design, with the aim of preventing hazards before substances reach markets or the environment.
Alexandra Maertens, Thomas Hartung, Thomas Hartung, Thomas Hartung   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

In vitro and in silico Models to Study Mosquito-Borne Flavivirus Neuropathogenesis, Prevention, and Treatment

Frontiers in Cellular and Infection Microbiology, 2019
Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
Megan Chesnut, Laura S. Muñoz, Laura S. Muñoz, Georgina Harris, Dana Freeman, Lucio Gama, Lucio Gama, Carlos A. Pardo, Carlos A. Pardo, David Pamies, David Pamies   +10 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

AI snake oil? A risk/benefit analysis for toxicology

Frontiers in Artificial Intelligence
Artificial intelligence (AI) is increasingly used to support predictive, mechanistic, and human-relevant toxicology at scale. However, its integration into regulatory science - particularly in drug development - remains uneven, because encouraging ...
Thomas Hartung, Thomas Hartung, Thomas Hartung, Mohan Rao, Mamta Behl, Alexandra Maertens   +5 more
doaj   +1 more source