Results 51 to 60 of about 55,459 (256)
International cooperation for alternatives to animal testing
Folia Pharmacologica Japonica, 2011 動物実験代替法（以下，代替法と記す）の開発を促すために各国に設立された代替法バリデーションセンターの協調を図るため，2009年に日米欧カナダの参加で，代替試験法協力国際会議（ICATM: International Cooperation on Alternative Test Methods）の覚書が交わされ，代替法の開発に国際協調がより重要視されることになった．さらに，2011年には韓国の追加参入が決まり，新たな覚書が交わされた．このICATMの取り決めに準じた日本動物実験代替法評価センター（JaCVAM: Japanese Center for the Validation of Alternative Methods）の活動状況および今後の国際対応についてまとめた．本来なら ...
openaire +3 more sources
Giving meaning to alternative methods to animal testing
ALTEX, 2018 The 3 rd edition of the advanced theoretical-training course “ Giving meaning to alternative methods to animal testing ” was held in Genoa on July 6-7, 2017. The theoretical modules included talks by specialists from companies engaged in the field of advanced in vitro technologies, who offered participants the possibility to try out their technologies ...
Scanarotti C +7 more
openaire +3 more sources
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Next generation validation for next generation risk assessment
Frontiers in ToxicologyNext generation risk assessment (NGRA) demands a fundamental transformation in how toxicological test methods are validated. Traditional validation approaches, designed for animal tests and mainly for simple in vitro methods, are increasingly inadequate ...
Karolina Kopańska +5 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Evidence-based AI: from trailblazer to trustblazer?
Frontiers in Artificial IntelligenceAgentic AI systems can plan, call tools, and coordinate specialized sub-agents, enabling multi-step scientific workflows that exceed what single-model text generation can reliably deliver.
Thomas Luechtefeld +2 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The (misleading) role of animal models in drug development
Frontiers in Drug DiscoveryAnimals like mice and rats have long been used in medical research to help understand disease and test potential new treatments before human trials. However, while animal studies have contributed to important advances, too much reliance on animal models ...
Thomas Hartung, Thomas Hartung
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Give meaning to alternative methods to animal testing
ALTEX, 2019 n ...
Arti Ahluwalia, Anna Maria Bassi
openaire +4 more sources