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Metabolomics in Preclinical Drug Safety Assessment: Current Status and Future Trends
MetabolitesMetabolomics is emerging as a powerful systems biology approach for improving preclinical drug safety assessment. This review discusses current applications and future trends of metabolomics in toxicology and drug development.
Fenna Sillé, Thomas Hartung
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Frontiers in Cellular and Infection Microbiology, 2019 Mosquito-borne flaviviruses can cause disease in the nervous system, resulting in a significant burden of morbidity and mortality. Disease models are necessary to understand neuropathogenesis and identify potential therapeutics and vaccines.
Megan Chesnut +10 more
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The development of laboratory animal science and animal care of legislation and the consummation [PDF]
, 2012 Laboratory animal science is the use of non-human animals in experiments to obtain new knowledge and new technologies in biomedical research and testing.
Shizhong, Zhou
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Tests of fit for the logarithmic distribution [PDF]
, 2008 Smooth tests for the logarithmic distribution are compared with three tests: the first is a test due to Epps and is based on a probability generating function, the second is the Anderson-Darling test, and the third is due to Klar and is based on the ...
Best, DJ, Rayner, JCW, Thas, Olivier
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AI snake oil? A risk/benefit analysis for toxicology
Frontiers in Artificial IntelligenceArtificial intelligence (AI) is increasingly used to support predictive, mechanistic, and human-relevant toxicology at scale. However, its integration into regulatory science - particularly in drug development - remains uneven, because encouraging ...
Thomas Hartung +5 more
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A Scientific Roadmap for Antibiotic Discovery: A Sustained and Robust Pipeline of New Antibacterial Drugs and Therapies is Critical to Preserve Public Health [PDF]
, 2016 In recent decades, the discovery and development of new antibiotics have slowed dramatically as scientific barriers to drug discovery, regulatory challenges, and diminishing returns on investment have led major drug companies to scale back or abandon ...
Allan Coukell +5 more
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Next generation validation for next generation risk assessment
Frontiers in ToxicologyNext generation risk assessment (NGRA) demands a fundamental transformation in how toxicological test methods are validated. Traditional validation approaches, designed for animal tests and mainly for simple in vitro methods, are increasingly inadequate ...
Karolina Kopańska +5 more
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A worldwide survey on the use of animal‐derived materials and reagents in scientific experimentation
Engineering in Life Sciences, 2022 The use of cell and tissue‐based methods in basic, applied and regulatory science has been increasing exponentially. Animal‐derived components, including serum, coating materials, growth factors and antibodies are routinely used in cell/tissue cultures ...
Manuela Cassotta +7 more
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International cooperation for alternatives to animal testing
Folia Pharmacologica Japonica, 2011 動物実験代替法（以下，代替法と記す）の開発を促すために各国に設立された代替法バリデーションセンターの協調を図るため，2009年に日米欧カナダの参加で，代替試験法協力国際会議（ICATM: International Cooperation on Alternative Test Methods）の覚書が交わされ，代替法の開発に国際協調がより重要視されることになった．さらに，2011年には韓国の追加参入が決まり，新たな覚書が交わされた．このICATMの取り決めに準じた日本動物実験代替法評価センター（JaCVAM: Japanese Center for the Validation of Alternative Methods）の活動状況および今後の国際対応についてまとめた．本来なら ...
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Giving meaning to alternative methods to animal testing
ALTEX, 2018 The 3 rd edition of the advanced theoretical-training course “ Giving meaning to alternative methods to animal testing ” was held in Genoa on July 6-7, 2017. The theoretical modules included talks by specialists from companies engaged in the field of advanced in vitro technologies, who offered participants the possibility to try out their technologies ...
Scanarotti C +7 more
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