Results 31 to 40 of about 87,604,756 (316)

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology

, 2022
S.327-378Models of the outer epithelia of the human body - namely the skin, the intestine and the lung - have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model
Fabian, E., Kandarova, H., Gordon, S., Khare, S., Marx, U., Prieto, P., Leist, M., Caloni, F., Constant, S., Hartung, T., Krug, H.F., Davies, D.E., Tralau, T., Guzman, C.A., Metzger, M., Roggen, E.L., Daneshian, M., Lehr, C.-M., Hasiwa, N., Roberts, M.S., Kneuer, C., Hayden, P., Dandekar, G., Walles, Heike, Bouwstra, J., Ott, K., Lian, G., Braak, C. van den, Haltner, E.   +28 more
core   +1 more source

Predicting toxicity of chemicals: software beats animal testing

EFSA Journal, 2019
We created earlier a large machine‐readable database of 10,000 chemicals and 800,000 associated studies by natural language processing of the public parts of Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) registrations until
Thomas Hartung
doaj   +1 more source

Associations between clinical signs and pathological findings in toxicity testing

, 2021
Animal testing for toxicity assessment of chemicals and pharmaceuticals must take the 3R principles into consideration. During toxicity testing in vivo, clinical signs are used to monitor animal welfare and to inform about potential toxicity.
Silva, Antero Vieira,, Silva, Antero, V,, Liiv, E, Tornqvist, E, Öberg, Mattias,, Liiv, Elin,, Törnqvist, Elin,, Öberg, Mattias, Platzack, Björn,, Silva, Antero, Platzack, Björn, Norinder, U, Liiv, Elin, Törnqvist, Elin, Silva, AV, Platzack, B, Oberg, M, Norinder, Ulf,   +17 more
core   +1 more source

The “Big Three” in biocompatibility testing of medical devices: implementation of alternatives to animal experimentation—are we there yet?

Frontiers in Toxicology
Biocompatibility testing ensures the safety of medical devices by assessing their compatibility with biological systems and their potential to cause harm or adverse reactions.
H. Kanďárová, P. Pôbiš
semanticscholar   +1 more source

Alternatives to Animal Experimentation [PDF]

, 1983
Alternatives to animal experimentation are highly touted today by animal welfare advocates. Their campaign for adoption of alternatives has caused much discussion and debate within and outside of the biomedical community. The purpose of this paper was to
Niemi, Steven M.
core   +5 more sources

E-cigarettes and the need and opportunities for alternatives to animal testing.

ALTEX, 2016
E-cigarettes have become within only one decade an important commodity, changing the market of the most mass-killing commercial product. While a few years ago estimates suggested that in the course of the 21st century one billion people would die ...
T. Hartung
semanticscholar   +1 more source

Towards learning and memory risk assessment with human brain organoids: barriers and opportunities

Frontiers in Toxicology
Neurodevelopmental conditions, including autism spectrum disorder, intellectual disability, and learning disabilities, as well as neurodegenerative disorders, affect millions of people in the United States alone.
Ronit Mohapatra, Dowlette-Mary Alam El Din, Hanyu Zhao, Hanyu Zhao, Thomas Hartung, Thomas Hartung, Lena Smirnova   +6 more
doaj   +1 more source

Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory

Communications Biology
Brain Microphysiological Systems, including neural organoids derived from human induced pluripotent stem cells, offer a unique lens to study the intricate workings of the human brain.
Dowlette-Mary Alam El Din, Leah Moenkemoeller, Alon Loeffler, Forough Habibollahi, Jack Schenkman, Amitav Mitra, Tjitse van der Molen, Lixuan Ding, Jason Laird, Maren Schenke, Erik C. Johnson, Brett J. Kagan, Thomas Hartung, Lena Smirnova   +13 more
doaj   +1 more source

Brain organoids and organoid intelligence from ethical, legal, and social points of view

Frontiers in Artificial Intelligence
Human brain organoids, aka cerebral organoids or earlier “mini-brains”, are 3D cellular models that recapitulate aspects of the developing human brain.
Thomas Hartung, Thomas Hartung, Itzy E. Morales Pantoja, Lena Smirnova   +3 more
doaj   +1 more source

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source