Results 201 to 210 of about 4,831,623 (248)

Editorial: Shaping the future of predictive toxicology: addressing challenges and new approach methodologies

Frontiers in Pharmacology
Gladys Ouedraogo, Elisabet Berggren, Thomas Hartung, Thomas Hartung   +3 more
doaj   +1 more source

Mitigating antimicrobial resistance in the animal industry: reduction strategies and alternatives to antibiotics. [PDF]

Front Vet Sci
Al-Khalaifah H, Al-Surrayai T.
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

The Role that Biobanks Can Play in Driving Animal-Free Biomedical Research. [PDF]

Expert Rev Mol Med
Speirs V, Walker A.
europepmc   +1 more source

Evaluating GenAI‐produced feedback on undergraduate bioscience essays against good higher education feedback practice

FEBS Open Bio, EarlyView.
This pilot study investigates the potential of Generative AI to provide formative feedback to students. ChatGPT was prompted to provide feedback on Year 1 Bioscience essays, which were evaluated against established good feedback practices. GenAI‐authored feedback had useful elements, but was limited in scope. GenAI may have potential to provide instant,
Annabel Court, Nigel Francis, Andrew Shore, Stephen Rutherford   +3 more
wiley   +1 more source

Making the Case for Organ-on-Chip Platforms in Long-Acting Therapeutics Development. [PDF]

Adv Healthc Mater
Gowans C, Khedr A, Georgiou PG, Arik N, Sen O, Rannard SP, McDonald TO, Tapeinos C.   +7 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Plant-Based Diets in Adolescence: Cardiometabolic Benefits, Developmental Risks, and the Role of Fortification. [PDF]

Nutrients
Simionescu B, Murgu AM, Mihai A, Lupu VV, Buzilă ER, Grudnicki A, Roșu MF, Lupu A, Novac B, Anton E, Novac O, Temneanu OR.   +11 more
europepmc   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Panel Backs Animal Testing Alternatives

, 1996

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