Results 201 to 210 of about 2,294,578 (257)

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Angeliki G. Filippatou, Susana Dominguez‐Penuela, David Acero‐Garces, Georgios Gakis, Matthew D. Smith, Yasmin Resto, Maria Reyes‐Mantilla, Haiwen Chen, Isabella Hernandez, Yana Said, Andrea Salazar‐Camelo, Christina Huynh, Alessia Tassoni, Ted Yednock, Rick Artis, Yaisa Andrews‐Zwilling, Scott D. Newsome, Shiv Saidha, Pavan Bhargava, Ellen M. Mowry, Kathryn C. Fitzgerald, Peter A. Calabresi, Carlos A. Pardo, Elias S. Sotirchos   +23 more
wiley   +1 more source

A Two‐Stage Plasma Biomarker Algorithm Reduces Amyloid PET Use and the p‐Tau217 Gray Zone

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma p‐Tau217 leaves 30%–50% of patients in an indeterminate “gray zone” often requiring Aβ‐PET. We developed GRAD (Gatekeeper‐Reflex for Alzheimer's Disease), a two‐stage Aβ‐positivity prediction model to improve classification while reserving Aβ‐PET for residual uncertainty.
Harthik Parankusham, Casey Vanderlip, Colin Birkenbihl, Eashwar Krishna, Chizobam Ugboaja, Andrew E. Budson, Brandon Frank, for the Alzheimer's Disease Neuroimaging Initiative   +7 more
wiley   +1 more source

Improving the Diagnostic Accuracy of Plasma Alzheimer's Disease Biomarkers With Objective and Subjective Cognitive Screening

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Blood‐based biomarkers are increasingly used to identify Alzheimer's disease (AD) pathology and may play an important role in early disease screening and participant selection for clinical trials. However, their performance across stages of cognitive impairment remains unclear. This study examined whether plasma biomarkers differ in
Maryam Abdolmaleki, Leslie S. Gaynor, Dandan Liu, Timothy J. Hohman, Katherine A. Gifford, Henrik Zetterberg, Angela L. Jefferson, Corey J. Bolton   +7 more
wiley   +1 more source

Consumers’ Concerns and Perceptions of Farm Animal Welfare [PDF]

Animals, 2020
P. 1-13In this paper, we explore the evolution of consumers’ perceptions and concerns about the effects that intensification of production systems could have on the welfare of farm animals.
Marta E Alonso, José R González, Juan Manuel Lomillos   +2 more
exaly   +2 more sources

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Animal welfare

2022
The aim of this chapter is to provide the reader with guidance and relevant sources related to implementation of animal welfare in husbandry practices, design, and daily operations of animal facility. Specifically, the authors aim to address the following key requirements as indicated in the Directive 2010/63:- To indicate how good welfare can promote ...
Galligioni, V., Boruc, O., Fuchs, H., Hrabě de Angelis, M., Zarattini, P.   +4 more
openaire   +2 more sources

Wild animal welfare

Veterinary Record, 2016
YOUR correspondents Mark Jones and Alistair MacMillan ( VR , February 20, 2016, vol 178, p 195) seem to think that …
Mark, Jones, Alastair, MacMillan
openaire   +4 more sources

Fundraising for animal welfare

Veterinary Record, 2023
BVA's President Malcolm Morley is stepping out for animal welfare…
openaire   +2 more sources

Animal Welfare and Animal Rights

2018
In this chapter a distinction is made between animal welfare, for which a scientific approach is possible, and animal rights, which requires an ethical consideration. Our relationship with animals has changed most for food-producing animals, having evolved from one of necessity to one of exploitation of many of the managed animals.
Phillips, Clive J. C., Kluss, Katrina
openaire   +3 more sources

Animal behavior and animal welfare

Journal of the American Veterinary Medical Association, 1991
Summary The value of behavioral techniques in assessing animal welfare, and in particular assessing the psychological well being of animals, is reviewed. Using cats and horses as examples, 3 behavioral methods are presented: (1) comparison of behavior patterns and time budgets; (2) choice tests; and (3) operant conditioning. The behaviors of intact and
openaire   +2 more sources