Results 101 to 110 of about 122,873 (307)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Animales peligrosos entre los embera
, 2022 spa: Este libro explora las ideas, prácticas, concepciones y nociones que diversos grupos étnicos y sociales establecen al percibir, representar, usar e interrelacionarse con las entidades no humanas (en este caso la fauna), para vislumbrar cómo cada ...
Tapí Rito, Bilardo
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2023 La presente investigación resulta necesaria debido a la falta de diferenciación entre los derechos de la naturaleza en general, con los derechos que tiene los animales en particular, que puedan cubrir sus necesidades específicas, lo que deja carta ...
Gualli Ávila, Damián Sahid
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Tenencia y adquisición responsable de animales
, 2011 La Secretaría de Educación del Distrito (SED), desde el Plan Sectorial de Educación 2008-2012 “Educación de Calidad para una Bogotá Positiva”, incluye la formación para proteger y conservar el ambiente dentro de sus acciones para la transformación ...
Jiménez, Ricardo +3 more
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
El dilema del huevo y la gallina
Análisis Jurídico - PolíticoHaciendo uso de la analogía del dilema del huevo y la gallina, así como de la liberación de humanos esclavizados, la segregación y el apartheid, y recurriendo a definiciones de la corriente principialista de la bioética, la ética ciudadana y la bioética
Carlos Alberto Crespo Carrillo
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source