Results 131 to 140 of about 3,851,845 (379)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

De bestias sobrenaturales a fauna de la naturaleza: las especies animales, su significación y su relación con el individuo a la luz de la expansión del siglo XII en Santiago de Compostela

Ítaca
El artículo toma como centro la consideración de las especies animales y la relación que mantienen con las poblaciones e individuos para reinterpretar su significación en una perspectiva nueva: la de los cambios sociales y económicos de la expansión de ...
Xosé M. Sánchez Sánchez
doaj   +1 more source

Animales, animales y más animales

, 2008
ESP
openaire   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Animales reales en el arte, o sobre los límites éticos de la capacidad creadora. [PDF]

, 2007
Este trabajo versa sobre los límites éticos de la utilización de animales reales (vivos o muertos) en el arte contemporáneo. Para ello, parte de la defensa de obligaciones éticas directas hacia los animales y de la revisión de cualquier forma de ...
Velayos Castelo, Carmen
core  

La antropomorfización del vínculo humano-animal en las dinámicas familiares: una revisión documental

Pensamiento Americano
Introducción: El estudio de la interacción entre humanos y animales de compañía ha cobrado relevancia debido a los cambios en las dinámicas sociales actuales.
Maria Cristina Correa Duque, Anyerson Stiths Gómez Tabares, Valentina Posada Hoyos   +2 more
doaj   +1 more source

Architectures animales

Histoire de l'art, 2001
Building for animals. If Historians have, for a long time, underlined and studied the plentiful presence of animals in architecture, they paid less attention, at least in France, to the buildings for animals. This article deals with the present state of studies and new possibilities from examples concerning animals : zoological gardens and circus
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Domestications animales

Calenda, 2000
VIIe colloque international de l'association "L'Homme et l'Animal" Lyon (France) Jeudi 22, vendredi 23 et samedi 24 novembre 2001 Axes du colloque A - Les catégories culturelles et ...
openaire   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source