Results 31 to 40 of about 1,530,780 (243)

Development of a real-time loop-mediated isothermal amplification assay for detection of porcine circovirus 3

BMC Veterinary Research, 2019
Background Porcine circovirus type 3 (PCV3) is an emerging circovirus species, that has been reported in major pig-raising countries including the United States, China, South Korea, Brazil, Spain, and Poland.
Huanan Wang, Xiangnan Liu, Fanwen Zeng, Tongyuan Zhang, Yuexiao Lian, Miaoli Wu, Li Xiao, Yujun Zhu, Yu Zhang, Meili Chen, Ren Huang, Manlin Luo, Feng Cong, Pengju Guo   +13 more
doaj   +1 more source

Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody

Scientific Reports, 2021
Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer in the clinic. Further discovery of novel drugs or therapeutic protocols that enhance efficacy requires reliable animal models that recapitulate human immune responses to ICI
Ikumi Katano, Asami Hanazawa, Iyo Otsuka, Takuya Yamaguchi, Misa Mochizuki, Kenji Kawai, Ryoji Ito, Motohito Goto, Takahiro Kagawa, Takeshi Takahashi   +9 more
doaj   +1 more source

Identificationof a novel linear epitope on the porcine reproductive and respiratory syndrome virus nucleocapsid protein, as recognized by a specific monoclonal antibody

Frontiers in Immunology, 2023
IntroductionPorcine reproductive and respiratory syndrome virus (PRRSV) remains one of the most threatening pathogens of swine. The nucleocapsid (N) protein is the major structural protein of the virus and has been used as a PRRSV diagnostic antigen due ...
Yuening Cheng, Miaoli Wu, Li Xiao, Mengdi Zhang, Bihong Huang, Feng Cong, Li Yi   +6 more
doaj   +1 more source

Isolation and characterization of Bordetella pseudohinzii in mice in China

Animal Models and Experimental Medicine, 2019
We report on the first detection and isolation of B. pseudohinzii (Bordetella pseudohinzii) in laboratory mice in China. Forty‐one B. pseudohinzii strains were isolated from 3094 mice in 33 different laboratory animal facilities in southern China.
Lei Ma, Shuwu Huang, Yinzhu Luo, Fangui Min, Lifang He, Meiling Chen, Jinchun Pan, Yu Zhang, Jing Wang   +8 more
doaj   +1 more source

Prediction of Compound Synthesis Accessibility Based on Reaction Knowledge Graph

Molecules, 2022
With the increasing application of deep-learning-based generative models for de novo molecule design, the quantitative estimation of molecular synthetic accessibility (SA) has become a crucial factor for prioritizing the structures generated from ...
Baiqing Li, Hongming Chen
doaj   +1 more source

Alternatives to Carbon Dioxide—Taking Responsibility for Humanely Ending the Life of Animals

Animals, 2019
Carbon dioxide (CO2) is commonly used to kill rodents. However, a large body of research has now established that CO2 is aversive to them. A multidisciplinary symposium organized by the Swiss Federal Food Safety and Veterinary Office discussed the ...
Shannon Axiak Flammer, Chantra Eskes, Ingrid Kohler, Awilo Ochieng Pernet, Peter Jakob, Michael Marahrens, Thomas C. Gent, Huw Golledge, Dan Weary   +8 more
doaj   +1 more source

General Anesthetics Commonly Used for Laboratory Animals

Shiyan dongwu yu bijiao yixue, 2022
General anesthetics used for laboratory animals are mostly controlled drugs, and are subject to strict supervision by the competent government agency in China.
LU Xiao, YU Lingzhi, CHOU Sonja Tsung-Ying, LI Ruying, CHEN Wenjun, JIANG Shanxiang   +5 more
doaj   +1 more source

Systemic Candida parapsilosis Infection Model in Immunosuppressed ICR Mice and Assessing the Antifungal Efficiency of Fluconazole

Veterinary Medicine International, 2015
This study was to establish a systemic C. parapsilosis infection model in immunosuppressed ICR mice induced by cyclophosphamide and evaluate the antifungal efficiency of fluconazole. Three experiments were set to confirm the optimal infectious dose of C.
Yu’e Wu, Fangui Min, Jinchun Pan, Jing Wang, Wen Yuan, Yu Zhang, Ren Huang, Lixin Zhang   +7 more
doaj   +1 more source

Establishment and evaluation of a transgenic mouse model of arthritis induced by overexpressing human tumor necrosis factor alpha

Biology Open, 2016
Tumor necrosis factor alpha (TNFα) plays a key role in the pathogenesis of rheumatoid arthritis (RA). Blockade of TNFα by monoclonal antibody has been widely used for the therapy of RA since the 1990s; however, its mechanism of efficacy, and potential ...
Ge Li, Yu'e Wu, Huanhuan Jia, Lu Tang, Ren Huang, Yucai Peng, Yu Zhang   +6 more
doaj   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source