Results 41 to 50 of about 7,481,737 (359)
Scientific Reports, 2021 Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of cancer in the clinic. Further discovery of novel drugs or therapeutic protocols that enhance efficacy requires reliable animal models that recapitulate human immune responses to ICI
Ikumi Katano +9 more
doaj +1 more source
Frontiers in Immunology, 2023 IntroductionPorcine reproductive and respiratory syndrome virus (PRRSV) remains one of the most threatening pathogens of swine. The nucleocapsid (N) protein is the major structural protein of the virus and has been used as a PRRSV diagnostic antigen due ...
Yuening Cheng +6 more
doaj +1 more source
Innovations and advances in modelling and measuring pain in animals
Nature Reviews Neuroscience, 2021 Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past decade as a result of technological advancements, the continued dearth of translational progress and the emphasis that funding institutions and journals have ...
K. Sadler, J. Mogil, C. Stucky
semanticscholar +1 more source
Isolation and characterization of Bordetella pseudohinzii in mice in China
Animal Models and Experimental Medicine, 2019 We report on the first detection and isolation of B. pseudohinzii (Bordetella pseudohinzii) in laboratory mice in China. Forty‐one B. pseudohinzii strains were isolated from 3094 mice in 33 different laboratory animal facilities in southern China.
Lei Ma +8 more
doaj +1 more source
Prediction of Compound Synthesis Accessibility Based on Reaction Knowledge Graph
Molecules, 2022 With the increasing application of deep-learning-based generative models for de novo molecule design, the quantitative estimation of molecular synthetic accessibility (SA) has become a crucial factor for prioritizing the structures generated from ...
Baiqing Li, Hongming Chen
doaj +1 more source
Enrichment for Laboratory Zebrafish—A Review of the Evidence and the Challenges
Animals, 2021 Simple Summary The zebrafish is one of the most commonly used animals in scientific research, but there remains a lack of consensus over good practice for zebrafish housing and care.
Chloe Stevens +2 more
semanticscholar +1 more source
Alternatives to laboratory animals : ATLA, 2018 Recurrent acute and/or chronic stress can affect all vertebrate species, and can have serious consequences. It is increasingly and widely appreciated that laboratory animals experience significant and repeated stress, which is unavoidable and is caused ...
Jarrod Bailey
semanticscholar +1 more source
Frontiers in Genetics, 2018 Zearalenone (ZEA), one of the most prevalent estrogenic mycotoxins, is mainly produced by Fusarium fungi and has been proven to affect the reproductive capacity of animals.
Guo-Liang Zhang +3 more
semanticscholar +1 more source
Biology Open, 2016 Tumor necrosis factor alpha (TNFα) plays a key role in the pathogenesis of rheumatoid arthritis (RA). Blockade of TNFα by monoclonal antibody has been widely used for the therapy of RA since the 1990s; however, its mechanism of efficacy, and potential ...
Ge Li +6 more
doaj +1 more source
Historical development path of the Laboratory of biochemistry of adaptation and ontogenesis of animals [PDF]
, 2020 The article presents a historical development path of the Laboratory of biochemistry of adaptation and ontogenesis of animals which began with the founding of the Ukrainian Research Institute of Physiology and Biochemistry of Farm Animals in 1960. At the
H. V. Klymets +2 more
core +1 more source