Results 191 to 200 of about 3,256,140 (321)

TRIM40 Drives Pathological Cardiac Hypertrophy and Heart Failure via Ubiquitination of PKN2

open access: yesAdvanced Science, EarlyView.
This study identifies the E3 ligase TRIM40 as a key driver of pathological cardiac hypertrophy. TRIM40 binds PKN2 via its B‐box domain and, through its C29‐dependent catalytic activity, mediates K63‐linked ubiquitination of PKN2. This modification enhances PKN2 phosphorylation at Ser815, thereby driving hypertrophy.
Risheng Zhao   +12 more
wiley   +1 more source

Microbiota in the Early Lives of Sheep: A Short Overview on the Rumen Microbiota. [PDF]

open access: yesAnimals (Basel)
Bevilacqua A   +5 more
europepmc   +1 more source

Newborn infants perceive abstract numbers

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2009
Véronique Izard   +3 more
semanticscholar   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

open access: yesAdvanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling   +17 more
wiley   +1 more source

Stress-induced hyperphagia? Characterising the activity of the ghrelin axis in male rats with high anxiety behaviour. [PDF]

open access: yesJ Neuroendocrinol
Hornsby AKE   +8 more
europepmc   +1 more source

Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs.

open access: yesAmerican Journal of Respiratory Cell and Molecular Biology, 2015
N. Keiser   +14 more
semanticscholar   +1 more source

A Universal Metal–Flavonoid Coating Strategy: Engineering Biomaterials for Diabetic Bone Regeneration

open access: yesAdvanced Science, EarlyView.
Construction of metal–flavonoid functionalized coatings on conventional bone repair materials. A one‐pot method is used to directly construct multifunctional metal–flavonoid coatings on the surface of traditional bone repair materials by selecting metal ions with osteogenic/angiogenic properties and flavonoids with reactive oxygen species scavenging ...
Chen Yang   +11 more
wiley   +1 more source

Noradrenergic modulation of pheromone-induced odor learning and brain activation in newborn rabbits. [PDF]

open access: yesSci Rep
Ducourneau EG   +6 more
europepmc   +1 more source

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