Results 31 to 40 of about 1,457,674 (303)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Pathologie associée à une carence en vitamine A dans une ferme laitière marocaine [PDF]

open access: yesTropicultura, 1984
Clinical signs associated with vitamin A deficiency in a Moroccan dairy farm. In a dairy farm of the Temara area (Morocco) various observed clinical manifestations were suggestive of vitamin A deficiency.
Mahin, L., Dewulf, M., Lakhdissi, H.
doaj  

Microbiological Aerosol, Particulate Matter Concentrations and Antibiotic Resistant Staphylococcus spp. in the Premises of Poland’s Oldest Agricultural School

open access: yesAtmosphere, 2021
Bioaerosol, particulate matter concentration and antibiotic resistance of airborne Staphylococcus was assessed in animal and public premises (classroom, sports hall, horse stable, cowshed, newborn calf shed and outdoor background control site) of Poland ...
Anna Lenart-Boroń   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Vaccination of pregnant guinea pigs with aromatic dependent Salmonella typhimurium to protect their newborns

open access: yesThe Iraqi Journal of Veterinary Medicine, 2006
Genetically altered stable non reverting aromatic dependent (aro) Salmonella typhimurium,strain SL1479 was administrated intramuscularly to healthy pregnant guinea pigs as alive vaccine.
Yousif A. A.
doaj   +1 more source

Pathological anxiety in animals [PDF]

open access: yes, 2008
selective breeding programmes in domestic and laboratory animals generally focus on physiological and/or anatomical characteristics. However, selection may have an (unintended) impact on other characteristics and may lead to dysfunctional behaviour that ...
Dep Gezondheidszorg Landbouwhuisdieren   +6 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

New techniques for producing transgenic animals - a mixed blessing from both the scientific and animal welfare perspectives [PDF]

open access: yes, 2014
A further increase in the use of genetically-modified animals will be against the European Union policy to move away from the use of animals in biomedical ...
Algemeen Onderzoek DGK   +3 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

When and How Do Children Start Producing A Languge?

open access: yesIdeas, 2019
This article discusses how a child speaks his first language. The first language spoken through several phases is called the semantic process, syntax and phonology. Newborn babies get their first language from their mother called mother tongue.
Musliadi Musliadi
doaj   +1 more source

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