Results 41 to 50 of about 130,526 (267)

Onasemnogene Abeparvovec in Type I Spinal Muscular Atrophy: 24‐Month Follow‐Up From the Italian Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane, Giorgia Coratti, Chiara Cutrì, Antonio Varone, Riccardo Masson, Adele D'Amico, Valeria Sansone, Sonia Messina, Federica Ricci, Chiara Ticci, Claudio Bruno, Caterina Agosto, Francesca Benedetti, Antonella Pini, Sabrina Siliquini, Massimiliano Filosto, Alberto Zambon, Ilaria Bitetti, Maria Rosaria Manna, Claudia Dosi, Riccardo Zanin, Stefano Parravicini, Roberto De Sanctis, Giulia Stanca, Michela Catteruccia, Michele Tosi, Irene Mizzoni, Emilio Albamonte, Valentina Franchino, Maria Sframeli, Ilaria Cavallina, Elena Procopio, Michele Sacchini, Simone Morando, Noemi Brolatti, Federica Trucco, Gaia Scarpini, Elena Briganti, Beatrice Berti, Concetta Palermo, Daniela Leone, Stefano C. Previtali, Eugenio Mercuri, the ITASMAC working group   +43 more
wiley   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source

Morphological and Morphometric Parameters of the Liver of Newborn Male Rabbits Alexander

Ветеринарная патология
Introduction. At present, the study of age-related issues of the liver structure in animals is one of the most important objectives of morphology, since liver diseases occupy one of the leading places among the nosologies causing death of newborn animals,
A. M. Manakov, S. M. Zavaleeva
doaj   +1 more source

Investigation of biochemical and physiological parameters of the newborn Saiga antelope (Saiga tatarica) in Gansu Province, China.

PLoS ONE, 2019
BACKGROUND:The Saiga antelope (Saiga tatarica) is a critically endangered species, and there has been limited success in restoring the population by captive breeding.
Xia Liu, James Blackar Mawolo, Xiaohua Du, Yingjie Zhou, Haifang Wang, Fayang Liu, Zhiqing He, Haqi Astika Marela   +7 more
doaj   +1 more source

BRONCHOPULMONARY ANASTOMOSES IN FŒETAL, NEWBORN AND ADULT ANIMALS [PDF]

Quarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1966
Anastomoses between the bronchial and pulmonary arteries were studied by means of neoprene casts and by injection of a radiopaque substance or dyes. In fœtal lambs and newborn kittens and puppies there were numerous precapillary connections between the two arterial systems, the bronchial arteries appearing as branches of the pulmonary artery.
openaire   +2 more sources

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

THE INHIBITORY EFFECT OF DEHYDROEPIANDROSTERONE ON THE ACTIVITY AND ISOENZYME PATTERNS OF LIVER GLUCOSE 6-PHOSPHATE DEHYDROGENASE DURING DIFFERENT STAGES OF GROWTH [PDF]

Journal of Sciences, Islamic Republic of Iran, 1990
The effect of dehydroepiandrosterone (DHEA) on the activity and isoenzyme patterns of liver glucose 6- phosphate dehydrogenase (G6PD) was investigated in rats during different stages of growth.
doaj  

NMR-Based Plasma Metabolomics at Set Intervals in Newborn Dairy Calves with Severe Sepsis

Mediators of Inflammation, 2018
The aim of this first study was to reveal the new potential biomarkers by a metabolomics approach in severe septic calves. Sepsis is a common cause of morbidity and mortality in newborn dairy calves.
Abdullah Basoglu, Ismail Sen, Gaia Meoni, Leonardo Tenori, Amir Naseri   +4 more
doaj   +1 more source

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source

The stress-related changes in the cerebral blood flow in newborn rats with intracranial hemorrhage: metabolic and endothelial mechanisms

Journal of Biomedical Photonics & Engineering, 2016
Neonatal brain hemorrhages is a major problem of future generation’s health due to the high rate of cognitive disability of newborns after vascular catastrophes in the brain.
Olga Sindeeva, Ekaterina Borisova, Arkady Abdurashitov, Ekaterina Zhinchenko, Artem Gekalyuk, Maria Ulanova, Aly Esmat Sharif, Victoria Razubaeva, Sergey Serov, Ludmila Yankovskaya, Valery V. Tuchin, Oxana Semyachkina-Glushkovskaya   +11 more
doaj   +1 more source