Results 121 to 130 of about 4,965,699 (338)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Painted Ferocity: The Social Behaviors of African Wild Dogs, Threats to Survival, and Resulting Conservation Initiatives [PDF]

open access: yes, 2018
African Wild Dogs (Lycaon pictus) are an endangered species of canid from Sub-Saharan Africa. They are very social communal hunters, and are capable of chasing down prey for long stretches of time. Wild dogs benefit a savannah ecosystem by regulating the
Valdes, Alexis
core   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

open access: yesMolecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair   +17 more
wiley   +1 more source

Incentives for Bushmeat Consumption and Importation among West African Immigrants, Minnesota, USA

open access: yesEmerging Infectious Diseases, 2017
The knowledge, attitudes, and practices surrounding bushmeat consumption and importation in the United States are not well described. Focus groups of West African persons living in Minnesota, USA, found that perceived risks are low and unlikely to deter ...
Emily Walz   +6 more
doaj   +1 more source

Health evaluation of free-ranging and captive pichis (Zaedyus Pichiy; Mammalia, Dasypodidae), in Mendoza province, Argentina [PDF]

open access: yes, 2009
The health of free-ranging and captive pichis (Zaedyus pichiy) was assessed in Mendoza Province, Argentina, between November 2001 and December 2006. Postmortem examinations of 150 confiscated and vehicle-killed pichis and clinical examinations of 139 ...
Aguilar, Roberto F.   +2 more
core   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Phytochemistry and Pharmacology of Sesquiterpenoids from Atractylodes DC. Genus Rhizomes

open access: yesMolecules
The rhizomes of the genus Atractylodes DC. consist of various bioactive components, including sesquiterpenes, which have attracted a great deal of research interest in recent years.
Zhengyi Qu   +5 more
doaj   +1 more source

Road-killed wild animals: a preservation problem useful for eco-epidemiological studies of pathogens [PDF]

open access: yes, 2010
Road-killed wild animals have been for years used for surveillance of vectors of zoonotic pathogens and may offer new opportunities for eco-epidemiological studies.
BAGAGLI, E   +4 more
core   +2 more sources

Home - About - Disclaimer - Privacy