Results 111 to 120 of about 3,008,330 (304)
No naturally occurring blood group antibodies were detected in the crossmatching of 25 giant pandas
Scientific ReportsThe giant panda (Ailuropoda melanoleuca) is a vulnerable species of ursid, endemic to China. With over eight million years of evolution, it is considered a living fossil.
Yonghua Yin +19 more
doaj +1 more source
The Journey of the Default Mode Network: Development, Function, and Impact on Mental Health
BiologyThe Default Mode Network has been extensively studied in recent decades due to its central role in higher cognitive processes and its relevance for understanding mental disorders.
Felipe Rici Azarias +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
From Cartilage to Matrix: Protocols for the Decellularization of Porcine Auricular Cartilage
BioengineeringThe shortage of tissues and damaged organs led to the development of tissue engineering. Biological scaffolds, created from the extracellular matrix (ECM) of organs and tissues, have emerged as a promising solution for transplants.
Ana Caroline dos Santos +9 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Making a difference on behalf of animals living in the wild: interview with Jeff McMahan
, 2015 Jeff McMahan currently holds the prestigious White’s Chair of Moral Philosophy at Oxford University. He has previously been a professor of philosophy at Rutgers University (USA). He has written extensively about theoretical and applied ethics, two of his
Pacheco Faria, Catia Gisela
core +1 more source
Genomic revelations: investigating rotavirus a presence in wild ruminants and its zoonotic potential
Frontiers in Veterinary ScienceIntroductionRotaviruses A (RVA) are a major cause of acute viral gastroenteritis in humans worldwide and are responsible for about two million hospitalizations per year.
Petra Šenica +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source