Results 151 to 160 of about 3,008,330 (304)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Tick-Borne Pathogens in Wild Cervids from Poland: A Molecular Survey on <i>Anaplasma phagocytophilum</i> and Piroplasms. [PDF]

Animals (Basel)
Sel E, Libertini G, Bertelloni F, Bilska-Zając E, Jodełko A, Ebani VV, Guardone L.   +6 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Prevalence of Erysipelothrix rhusiopathiae in tonsils of domestic pigs and wild boars in Sweden. [PDF]

Acta Vet Scand
Zoric M, Söderlund R, Bagge E, Eriksson H.   +3 more
europepmc   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

From Leaves to Roots: Seasonal Dynamics of Wild Boar (<i>Sus scrofa</i>) Use of Understory Plant Resources in a Forest-Agricultural Landscape of Central Poland. [PDF]

Animals (Basel)
Nasiadka P, Obidziński A, Perlińska-Teresiak M, Orłowska L.   +3 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

<i>Trichinella</i> detection in wild boar meat intended for private consumption: Insights from a European study. [PDF]

Food Waterborne Parasitol
Rodrigues M, Pozio E, Veneziano V, Jansen F, Lazou T, Dan SD, Różycki M, Petrović J, Vieira-Pinto M.   +8 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Regulation of <i>Caenorhabditis elegans</i> avoidance behavior toward <i>Pseudomonas aeruginosa</i> PA14 by the canonical Wnt signaling pathway. [PDF]

Front Mol Neurosci
Lin R, Zhao K, Zhang Q, Xiao X, Zhao Y, Zhao X, Zou W.   +6 more
europepmc   +1 more source