Results 161 to 170 of about 3,008,330 (304)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

A screen for stress-induced sleep genes in Caenorhabditis elegans reveals a role for glutamate signaling. [PDF]

Genetics
Howe Q, Kominick C, Pierce M, Gazzara G, Curtin CE, Diana S, Abboud FJ, Olenginski J, Frattara M, Brown T, McCarthy T, Conrad P, Yoslov L, Vemula R, Gargani A, Le E, Nelson MD.   +16 more
europepmc   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

The First Evidence of Intermittent Rectal Prolapse in a Wild Chimpanzee (Pan troglodytes). [PDF]

J Med Primatol
Shimada M, Yano W.
europepmc   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Improving Invasive Animal Institutions: A citizen-focused approach. A citizen-focused review of institutional arrangements for Invasive Animal management

, 2014
This report discusses rules and responsibilities, property rights, administration, funding and management and other 'institutional' issues that affect landholders, volunteers, businesses, community groups or other non-government organisations (NGO's ...
Martin, Paul, Marshall, Graham R, Le Gal, Elodie, Dickson, Katrina, Low Choy, Darryl   +4 more
core  

Epidemiological study and risk factors of internal parasite infections in wild boar (<i>Sus scrofa</i>) in Mazandaran Province, northern Iran. [PDF]

Parasite Epidemiol Control
Abolhasani Drounkola M, Salimi Bejestani MR, Changizi E.   +2 more
europepmc   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

"Badly Wrong" - Der Existenzialismus und J. M. Coetzees The Lifes of Animals

, 2014
Die Existenzphilosophie ist geprägt vom Nachdruck auf den existierenden Menschen, der sein Leben philosophisch zu durchdringen sucht. Diesem Leitgedanken verpflichtet, plädieren die hier vorliegenden Beiträge für eine Lebenskunst, die die sinnlichen und ...
Wild, Markus
core  

Factors Related to Wildlife Consumption, Contact, and Environmental Exposures Across Ethnic Communities in Border Provinces of Thailand: A Quantitative One Health Study. [PDF]

Int J Vet Sci Med
Suwannarong K, Thammasutti K, Thongkan W, Ponlap T, Boonlakorn W, Saisongkorh W, Sawatwong P, Khiewkhern S, Bubpa N, Saengkul C, Amonsin A.   +10 more
europepmc   +1 more source