Results 231 to 240 of about 1,833,719 (312)

Hierarchical Summary Statistics Encoding Across Primary Visual and Posterior Parietal Cortices

Advanced Science, EarlyView.
This study shows that mouse V1 simultaneously encodes the ensemble mean and variance of motion, providing a robust summary‐statistic representation that persists despite single‐neuron variability. These signals propagate to PPC, where they are transformed into abstract category representations during decision making.
Young‐Beom Lee, Oliver James, Gaeun Jung, Doyun Lee, Yee‐Joon Kim   +4 more
wiley   +1 more source

H5N1: How prepared are the US and UK for a pandemic? [PDF]

PLOS Glob Public Health
Read S, Sridhar D.
europepmc   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

<i>C. elegans</i> somatostatin/allatostatin C signaling regulates sleep, metabolism, survival, and memory via a sleep-active neuron. [PDF]

Sci Adv
Park B, Mohsen L, Busack I, Uhlig L, Rossi L, Pollmeier G, Geens E, Istiban MN, Mandal S, Savio RD, Beets I, Stetak A, Bringmann H.   +12 more
europepmc   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

The RNA-binding protein NOVA-1 regulates circRNA expression, alternative splicing, and aging in Caenorhabditis elegans. [PDF]

G3 (Bethesda)
Adeyemi E, Alshareef HZ, Bhat JM, Miura P, van der Linden AM.   +4 more
europepmc   +1 more source

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

Effects of environmental setting and diet on the gut microbial ecology of eastern hellbenders (Cryptobranchus alleganiensis alleganiensis). [PDF]

Anim Microbiome
Cummins C, Sutton W, McLeod T, Dallas JW, Ghotbi M, Vargas-Gastélum L, Alexander NR, Rurik AJ, McGinnity D, Reinsch SD, Sandonato P, Arbour J, Freake M, Ashley A, Ternes W, Culp E, Spatafora J, McPhail K, Stajich JE, Hardman R, Walker DM.   +20 more
europepmc   +1 more source

Endocytic Control of Cell‐Autonomous and Non‐Cell‐Autonomous Functions of p53

Advanced Science, EarlyView.
NUMB Ex3‐containing isoforms localize to the plasma membrane, where they recruit p53 through SNX9 and direct it to multivesicular bodies and exosomes. Exported p53 is taken up by neighboring cells and activates nuclear programs, revealing an intercellular, exosome‐based pathway that might help establish a tumor‐suppressive microenvironment.
Roberta Cacciatore, Andrea Basile, Stefano Freddi, Irene Schiano Lomoriello, Carlo Ribelle Zucca, Giuseppe Ciossani, Luigi Scietti, Alessandro Cuomo, Simona Ronzoni, Simone Pelicci, Mario Faretta, Elena Zaccheroni, Giuliana Pelicci, Vittoria Matafora, Angela Bachi, Rosalind Helen Gunby, Salvatore Pece, Sara Sigismund, Letizia Lanzetti, Ivan Nicola Colaluca, Pier Paolo Di Fiore   +20 more
wiley   +1 more source

TMacaque-FaceNet: Automatic Facial Recognition Based on Vision Transformer for Wild Tibetan Macaques. [PDF]

Animals (Basel)
Gao Q, Zhang L, Luo H, Lv Z, Xia D.
europepmc   +1 more source