Results 241 to 250 of about 3,008,330 (304)

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Occurrence and Diversity of Cryptosporidium spp. and Giardia duodenalis in Animals in Portugal: Novel Data and Public Health Implications. [PDF]

Zoonoses Public Health
Louro M, Lozano J, Lopes P, Alves P, Garret M, Vale C, Bernardino R, Petrucci-Fonseca F, Vieira J, Duarte L, Brazio E, Lopes AF, Mateus TL, de Carvalho LM, da Fonseca IP, Gomes J.   +15 more
europepmc   +1 more source

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Wild boar as a sentinel species for ecosystem health surveillance: A review. [PDF]

One Health
Barroso P, Gortázar C, Balseiro A.
europepmc   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Aggrecan deficiency does not increase susceptibility to estrogen-induced growth plate senescence. [PDF]

J Endocr Soc
Bendre A, Hadad H, Ottosson L, Ohlsson C, Windahl SH, Nilsson O.   +5 more
europepmc   +1 more source

Cross-sectional investigation of pathogenic Leptospira at the wildlife-livestock interface in a Cerrado-Atlantic Forest ecotone, Brazil. [PDF]

Trop Anim Health Prod
Moreira RQ, Soares PM, Ramos VDN, Mangueira RAF, Pires BC, de Araújo HL, Fenelon ACG, Lilenbaum W, Lima AMC.   +8 more
europepmc   +1 more source

Comparative Analysis of Leukocyte Proportions and Morphology in Wild Muridae and Arvicolinae Rodents. [PDF]

Biology (Basel)
Rekouti E, Rosmaraki EE, Mitsainas GP.
europepmc   +1 more source

Tick-borne bacterial pathogens in wildlife and their parasitizing ticks in Korea: A molecular epidemiological study. [PDF]

Parasites Hosts Dis
Lee YJ, Kim B, Hyun YS, Heo JW, Woo HM, Choi JW, Choi I, Kang YM, Rhee MH, Kwak D, Kim KT, Seo MG.   +11 more
europepmc   +1 more source

Interleukin-1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis. [PDF]

Adv Sci (Weinh)
Mazloum H, Buchholz S, Schifter H, Ameling S, Steil L, Becker BL, Hammer E, Homuth G, Völker U, Bröker BM, Zierke L, Weiss FU, Glaubitz J, Sendler M.   +13 more
europepmc   +1 more source