CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Understanding Urban Demand for Wild Meat in Vietnam: Implications for Conservation Actions [PDF]
Vietnam is a significant consumer of wildlife, particularly wild meat, in urban restaurant settings. To meet this demand, poaching of wildlife is widespread, threatening regional and international biodiversity.
Diogo Veríssimo +19 more
core +1 more source
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Parasites of the African painted dog (Lycaon pictus) in captive and wild populations: Implications for conservation [PDF]
The African painted dog (Lycaon pictus) is a highly endangered carnivore of sub- Saharan Africa, which in the last century has suffered a population decline of almost 99%. With only 3,000-5,500 animals remaining in the wild it is imperative to understand
Ash, Amanda
core
Episode 97: Obligations of Assistance and Wild Animals with Catia Faria
In this episode of Knowing Animals I am joined by Dr. Catia Faria. Catia is a Postdoctoral researcher at the Foundation for Science & Technology at the Centre for Ethics, Politics & Society, at the University of Minho in Portugal.
Faria, Catia, O'Sullivan, Siobhan
core +1 more source
Perspectives of genomics for genetic conservation of livestock [PDF]
Genomics provides new opportunities for conservation genetics. Conservation genetics in livestock is based on estimating diversity by pedigree relatedness and managing diversity by choosing those animals that maximize genetic diversity.
Windig, J.J., Engelsma, K.A.
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Molecular identification of trypanosomatids in wild animals
Diverse wild animal species can be reservoirs of zoonotic flagellate parasites, which can cause pathologic Chagas disease. The present study aimed to detect the natural occurrence of flagellate parasites through direct microscopic examination of the ...
Oliveira e Sousa, L. +13 more
core +1 more source
Bush Animal Attacks: Management of Complex Injuries in a Resource-Limited Setting. [PDF]
Though animal-related injuries and fatalities have been documented throughout the world, the variety of attacks by wild animals native to rural East Africa are less commonly described.
Kotecha Vihar R +5 more
core +1 more source

