Results 191 to 200 of about 9,215,153 (385)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Complications Following Orchiectomy in Stallions in Field Conditions: Descriptive Results and Predictors in a Study of 612 Cases. [PDF]

open access: yesAnimals (Basel)
Tyrnenopoulou P   +8 more
europepmc   +1 more source

Sow removal in commercial herds: Patterns and animal level factors in Finland

open access: hybrid, 2018
Paula Bergman   +6 more
openalex   +1 more source

Antidotes in food animal practice [PDF]

open access: bronze, 2005
Scott R. R. Haskell   +4 more
openalex   +1 more source

Animating through Animation

open access: yes, 2015
Research has found that young people not in education, employment or training (NEET) suffer disproportionately high levels of social adversities and are at greater risk of involvement in crime. Whilst policy-makers across many European jurisdictions have made NEET a focus for intervention, it is only very rarely that the voice of young people flows ...
openaire  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Regulation of microRNA function in animals

open access: yesNature reviews. Molecular cell biology, 2018
Luca F. R. Gebert, I. MacRae
semanticscholar   +1 more source

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