Results 231 to 240 of about 9,120,435 (385)

The assessment for potential thyroid-mediated endocrine disruption in amphibians: Clarification on the use of new methods and on the interpretation of changes in thyroid histology. [PDF]

EFSA J
European Food Safety Authority (EFSA), Baumann L, Baynes A, Bennekou SH, Crofton K, Dang Z, Degitz S, Fini JB, Gilbert M, Holbech H, Terron A, Van Duursen M, McVey E, Arena M, Kienzler A, Rizzuto S, Bouza LV, Wilks M.   +17 more
europepmc   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Necessity of individual VDJ-databases for annotating antibody heavy chain characteristics in non-human primates. [PDF]

Immunogenetics
Aartse A, Bakx JGJ, Mortier D, Hofman S, Mooij P, Claireaux M, Eggink D, Bogers WM, Remarque EJ, Corcoran MM, Hedestam GBK, Bontrop RE, van Gils MJ, Koopman G.   +13 more
europepmc   +1 more source

Animating through Animation

, 2015
Research has found that young people not in education, employment or training (NEET) suffer disproportionately high levels of social adversities and are at greater risk of involvement in crime. Whilst policy-makers across many European jurisdictions have made NEET a focus for intervention, it is only very rarely that the voice of young people flows ...
openaire  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Recent Advances in Nutritional Requirements and Metabolic Homeostasis Regulation of Animals Under Stress Conditions. [PDF]

Animals (Basel)
Li X, Li X, Wu Z, Wang K, Qiao R, Han X, Li X, Yang F, Yu T, Wang T, Bai J.   +10 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Distinct responses to non-autonomous UPR^ER mediated by glutamatergic and octopaminergic neurons. [PDF]

Commun Biol
Coakley AJ, Hruby AJ, Wang J, Bong A, Nair T, Ramos CM, Alcala A, Hicks D, Averbukh M, Dutta N, Moaddeli D, Pearson C, Siebrand CJ, de Los Rios Rogers M, Sahay A, Curran SP, Mullen PJ, Benayoun BA, Garcia G, Higuchi-Sanabria R.   +19 more
europepmc   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Seizure occurrence in FCD type II is predicted by lesion position and linked to cytoarchitectural alterations. [PDF]

Acta Neuropathol Commun
Procházková N, Olson CVL, Shariati N, Rozlivková JT, Populová J, Řehořová M, Kudláček J, Jiruška P, Novák O.   +8 more
europepmc   +1 more source