Results 261 to 270 of about 9,215,153 (385)

Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme

, 2015
Ahmed S. Abdelsamie, Emmanuel Bey, Emanuele M. Gargano, Chris J. van Koppen, Martin Empting, Martin Frotscher   +5 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Chrononutritional Effects of Cherry Consumption on Hepatic Lipid Profile. [PDF]

Nutrients
Ruiz de Azua MJ, Manocchio F, Cruz-Carrión Á, Arola-Arnal A, Gerstner C, Bernal C, Suárez M.   +6 more
europepmc   +1 more source

Hypothalamic insulin and glucagon-like peptide-1 levels in an animal model of depression and their effect on corticotropin-releasing hormone promoter gene activity in a hypothalamic cell line

, 2018
Jan Detka, Joanna Ślusarczyk, Anna Kurek, M. Kucharczyk, Tomasz Adamus, Paweł Konieczny, Marta Kubera, Agnieszka Basta‐Kaim, Władysław Lasoń, Bogusława Budziszewska   +9 more
openalex   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Intracellular innate immune surveillance devices in plants and animals

Science, 2016
Jonathan D. G. Jones, R. Vance, J. Dangl
semanticscholar   +1 more source

COMPASS Guidelines for Conducting Welfare-Focused Research into Behaviour Modification of Animals. [PDF]

Animals (Basel)
McGreevy PD, Mellor DJ, Freire R, Fenner K, Merkies K, Warren-Smith A, Uldahl M, Starling M, Lykins A, McLean A, Doherty O, Bradshaw-Wiley E, Quinn R, Wilkins CL, Christensen JW, Jones B, Ashton L, Padalino B, O' Brien C, Copelin C, Brady C, Henshall C.   +21 more
europepmc   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

The Guide for the Care and Use of Laboratory Animals.

ILAR journal, 2016

semanticscholar   +1 more source

Significant Impact of Schmallenberg Virus in Three Ruminant Farms: A Laboratory Experience. [PDF]

Vet Med Int
Guccione J, Longobardi V, Alterisio MC, Pagnini U, Ferrara G.   +4 more
europepmc   +1 more source