Clinical Pharmacology &Therapeutics, EarlyView.Marketing authorizations for oncology drugs are often based on single‐arm trials (SATs), and real‐world data‐based external comparator cohorts (ECCs) are increasingly explored to contextualize results. In retrospective studies, comparators may be identified by time of diagnosis but included based on time of relapse; such sampling strategies can ...
Mikkel Runason Simonsen +6 more
wiley +1 more source
Understanding chemical reactions through multimedia resolution data artistic educational tool (MRDAET). [PDF]
Protein SciPokojná H +4 more
europepmc +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Real‐world evidence (RWE) derived from real‐world data (RWD) can complement randomized controlled trials (RCTs), yet the validity of RWD relative to RCT data remains insufficiently characterized. We obtained post hoc consent and linked individual participant data from the US‐based INVESTED trial (2016–2019) with Medicare fee‐for‐service claims (2012 ...
Hanseul Cho +12 more
wiley +1 more source
Evaluating the effectiveness and acceptability of an animated educational tool for diabetic foot care: A randomized controlled trial and mixed-methods study in patients with active, in-remission and high-risk diabetic foot disease. [PDF]
J Diabetes InvestigLockhart M +9 more
europepmc +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.External control (EC) arms using routine data can be used as comparators in clinical trials under certain conditions. The objective of this study was to assess the ability of an EC arm to replicate outcomes of a randomized controlled trial (RCT) arm receiving the same treatment strategy in advanced stage classical Hodgkin lymphoma and serve as ...
Olivia Febvey‐Combes +8 more
wiley +1 more source
Recognizing the Importance of Design, Content, and Delivery Features of Health Animations for Preventive Health Behaviors: Realist Review. [PDF]
J Med Internet ResMcCorry K +7 more
europepmc +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Exposure‐response analyses supported a favorable benefit‐risk profile of Dato‐DXd at 6 mg/kg Q3W in patients with advanced nonsquamous NSCLC. Datopotamab deruxtecan (Dato‐DXd) is a trophoblast cell‐surface antigen‐2 (TROP2)‐directed antibody‐drug conjugate (ADC) that has demonstrated clinical activity in patients with NSCLC who have received prior ...
Ying Hong +10 more
wiley +1 more source
Development of an implementation package for asthma medication optimisation in the emergency department (AMEND): an evidence, theory and person-based approach. [PDF]
BMJ Open QualSkene I +7 more
europepmc +1 more source
Beyond the Human Negotiator: Generative AI and the Threshold of Autonomous Decision‐Making
Conflict Resolution Quarterly, EarlyView.ABSTRACT This article provides a comprehensive framework for understanding the role of artificial intelligence (AI) in negotiation, evaluating contemporary systems through the specific case study of Large Language Models (LLMs). To address the lack of established terminology, it first proposes a new typology distinguishing Negotiation Supported by AI ...
Martin Svatos
wiley +1 more source
The impact of culturally tailored video interventions for Long COVID among Hispanic/Latino populations. [PDF]
J Glob HealthJin X +7 more
europepmc +1 more source